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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Safety, Tolerability, and Effects of Sodium Bicarbonate Inhalation in Cystic Fibrosis

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Souza Gomez, Carla Cristina [1] ; Francisco Parazzi, Paloma Lopes [1] ; Clinckspoor, Karl Jan [2] ; Mauch, Renan Marrichi [1] ; Teixeira Pessine, Francisco Benedito [2] ; Levy, Carlos Emilio [3] ; Peixoto, Andressa Oliveira [1] ; Goncalves Oliveira Ribeiro, Maria Angela [1] ; Ribeiro, Antonio Fernando [1] ; Conrad, Douglas [4] ; Quinton, Paul Marquis [5] ; Lima Marson, Fernando Augusto [1, 6, 7] ; Ribeiro, Jose Dirceu [1]
Total Authors: 13
Affiliation:
[1] Univ Estadual Campinas, Fac Ciencias Med, Ctr Invest Pediat, Dept Pediat, 126 Tessalia Vieira de Camargo, BR-13083887 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Inst Quim, Dept Phys Chem, 336 Josue de Castro, BR-13083970 Campinas, SP - Brazil
[3] Univ Estadual Campinas, Fac Ciencias Med, Dept Clin Pathol, 126 Tessalia Vieira de Camargo, BR-13083887 Campinas, SP - Brazil
[4] Univ Calif San Diego, Sch Med, Div Pulm Crit Care & Sleep Med, 9500 Gilman Dr, La Jolla, CA 92093 - USA
[5] Univ Calif San Diego, Sch Med, Dept Pediat, 9500 Gilman Dr, La Jolla, CA 92093 - USA
[6] Univ Estadual Campinas, Fac Ciencias Med, Dept Med Genet & Genom Med, 126 Tessalia Vieira de Camargo, BR-13083887 Campinas, SP - Brazil
[7] Sao Francisco Univ, Lab Med & Human Genet, Postgrad Program Hlth Sci, Ave Sao Francisco de Assis 218, BR-12916900 Braganca Paulista, SP - Brazil
Total Affiliations: 7
Document type: Journal article
Source: CLINICAL DRUG INVESTIGATION; NOV 2019.
Web of Science Citations: 0
Abstract

Background Among the many consequences of loss of CFTR protein function, a significant reduction of the secretion of bicarbonate (HCO3-) in cystic fibrosis (CF) is a major pathogenic feature. Loss of HCO3- leads to abnormally low pH and impaired mucus clearance in airways and other exocrine organs, which suggests that NaHCO3 inhalation may be a low-cost, easily accessible therapy for CF. Objective To evaluate the safety, tolerability, and effects of inhaled aerosols of NaHCO3 solutions (4.2% and 8.4%). Methods An experimental, prospective, open-label, pilot, clinical study was conducted with 12 CF volunteer participants over 18 years of age with bronchiectasis and pulmonary functions classified as mildly to severely depressed. Sputum rheology, pH, and microbiology were examined as well as spirometry, exercise performance, quality-of-life assessments, dyspnea, blood count, and venous blood gas levels. Results Sputum pH increased immediately after inhalation of NaHCO3 at each clinical visit and was inversely correlated with rheology when all parameters were evaluated: {[}G ` (elasticity of the mucus) = - 0.241; G `' (viscosity of the mucus) = - 0.287; G{*} (viscoelasticity of the mucus) = - 0.275]. G{*} and G ` were slightly correlated with peak flow, forced expiratory volume in 1 s (FEV1), and quality of life; G `' was correlated with quality of life; sputum pH was correlated with oxygen consumption (VO2) and vitality score in quality of life. No changes were observed in blood count, venous blood gas, respiratory rate, heart rate, peripheral oxygen saturation of hemoglobin (SpO(2)), body temperature, or incidence of dyspnea. No adverse events associated with the study were observed. Conclusion Nebulized NaHCO3 inhalation appears to be a safe and well tolerated potential therapeutic agent in the management of CF. Nebulized NaHCO3 inhalation temporarily elevates airway liquid pH and reduces sputum viscosity and viscoelasticity. (AU)

FAPESP's process: 11/12939-4 - Association between polymorphisms in modifier genes in children and adolescent with allergic and non-allergic: mild, moderate and severe asthma
Grantee:Fernando Augusto de Lima Marson
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/12858-5 - Identification of prevalent mutations and clinical and functional characterization of children and adults with primary ciliary dyskinesia
Grantee:Fernando Augusto de Lima Marson
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 15/12183-8 - Identification of prevalent mutations and clinical and functional characterization of children and adults with primary ciliary dyskinesia
Grantee:Jose Dirceu Ribeiro
Support type: Regular Research Grants
FAPESP's process: 11/18845-1 - Association between polymorphisms in modifier genes in children and adolescent with allergic and non-allergic mild, moderate and severe asthma
Grantee:Jose Dirceu Ribeiro
Support type: Regular Research Grants