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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of surface pre-reacted glass-ionomer (S-PRG) eluate on Candida spp.: antifungal activity, anti-biofilm properties, and protective effects on Galleria mellonella against C. albicans infection

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Author(s):
Rossoni, Rodnei Dennis [1] ; de Barros, Patricia Pimentel [1] ; das Chagas Lopes, Lucas Alexandre [1] ; Ribeiro, Felipe Camargo [1] ; Nakatsuka, Toshiyuki [2] ; Kasaba, Hideto [2] ; Junqueira, Juliana Campos [1]
Total Authors: 7
Affiliation:
[1] UNESP Univ Estadual Paulista, Inst Sci & Technol, Dept Biosci & Oral Diag, Sao Jose Dos Campos - Brazil
[2] SHOFU Inc, Dept Res, Kyoto - Japan
Total Affiliations: 2
Document type: Journal article
Source: BIOFOULING; NOV 2019.
Web of Science Citations: 1
Abstract

Surface pre-reacted glass-ionomer (S-PRG) is a bioactive filler produced by PRG technology, which is applied to various dental materials. The inhibitory effects of S-PRG eluate against Candida, the most common fungal oral pathogen, were investigated. Minimum inhibitory concentrations (MIC) and anti-biofilm activities were tested against Candida albicans, Candida glabrata, Candida krusei, and Candida tropicalis. For the in vivo study, Galleria mellonella was used as a model to evaluate the effects of S-PRG on toxicity, hemocyte counts and candidiasis. The MIC of S-PRG ranged from 5 to 40% (v/v). S-PRG eluate exhibited anti-biofilm activity for all the Candida species tested. Furthermore, injection of S-PRG eluate into G. mellonella was not toxic to the larvae and protected G. mellonella against experimental candidiasis. In addition, S-PRG eluate inhibited biofilm formation by C. albicans, C. glabrata, C. krusei, and C. tropicalis and exerted protective effects on G. mellonella against experimental candidiasis in vivo. (AU)

FAPESP's process: 19/05664-0 - Exploring the caffeic acid (CA), caffeic acid phenethyl ester (CAPE) and artepillin c (ARTC) as new strategies to eliminate persisters cells of Candida albicans.
Grantee:Patricia Pimentel de Barros
Support type: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 17/02652-6 - Evaluation of the immunomodulatory and antifungal effects of caffeic acid (CA), caffeic acid phenethyl ester (CAPE) and artepillin C (ARC) on C. albicans and development of candidiasis in in vivo model hosts
Grantee:Patricia Pimentel de Barros
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/19219-3 - Identification of bioactive substances produced by Lactobacillus paracasei 28.4 for the control of oral candidiasis
Grantee:Rodnei Dennis Rossoni
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 18/21239-5 - Galleria mellonella in antimicrobial drug discovery: bioactive substances extracted from probiotic against Candida albicans persisters
Grantee:Rodnei Dennis Rossoni
Support type: Scholarships abroad - Research Internship - Post-doctor