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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Human platelet antigen polymorphisms and the risk of chronic Chagas disease cardiomyopathy

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do Carmo Correa, Deborah Elzita [1] ; Ayo, Christiane Maria [2] ; Laguila Visentainer, Jeane Eliete [1] ; Ambrosio-Albuquerque, Eliane Papa [3] ; Reis, Pamela Guimaraes [1] ; Brandao de Mattos, Cinara Cassia [2] ; Bestetti, Reinaldo Bulgarelli [4] ; de Mattos, Luiz Carlos [2] ; Sell, Ana Maria [1]
Total Authors: 9
[1] Univ Estadual Maringa, Dept Clin Anal & Biomed, Post Grad Program Biosci & Physiopath, Maringa, Parana - Brazil
[2] Fac Med Sao Jose do Rio Preto, Dept Mol Biol, Sao Jose Do Rio Preto, SP - Brazil
[3] Univ Estadual Maringa, Dept Biotechnol Cell Biol & Genet, Maringa, Parana - Brazil
[4] Univ Ribeirao Preto, Dept Med, Ribeirao Preto, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: PLATELETS; SEP 2019.
Web of Science Citations: 0

Human platelet antigen (HPA) polymorphisms are considered to be a risk factor for cardiac and vascular diseases, but the role of HPA in chronic Chagas disease cardiomyopathy (CCC) is not available. Therefore, the aim of this study was to investigate the association of HPA polymorphisms, HPA-1, HPA-2, HPA-3, HPA-5 and HPA-15, in the severity of left ventricular systolic dysfunction (LVSD) in CCC patients. For this, 229 CCC patients were separated into three groups: without LVSD, mild/moderate LVSD and severe LVSD. PCR-SSP was performed for HPA genotyping and the risk was assessed using SNPStats software. HPA-1 allele and genotype frequencies were lower in mild/moderate LVSD patients compared to other groups, without statistical significance. After stratified analyzes, the HPA-3a/3b genotype frequency was lower in women with severe LVSD compared to those without LVSD (OR:0.29; 95% CI: 0.10-0.84). In conclusion, HPA-3 variant could be a protection factor for CCC in the female patients. (AU)

FAPESP's process: 13/06580-9 - KIR genes, their HLA ligands and MICA gene polymorphism in ocular toxoplasmosis and in digestive form of Chagas disease
Grantee:Christiane Maria Ayo
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 11/08075-4 - Immunogenetic markers related to Chagas disease
Grantee:Luiz Carlos de Mattos
Support Opportunities: Regular Research Grants