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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mapping Research in the Obesity, Adipose Tissue, and MicroRNA Field: A Bibliometric Analysis

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Author(s):
Alves, Joao Manoel [1] ; Gomes Teles, Ramon Handerson [2] ; Gomes Gatto, Camila do Valle [3] ; Munoz, Vitor Rosetto [4] ; Cominetti, Marcia Regina [2] ; Garcia de Oliveira Duarte, Ana Claudia [1]
Total Authors: 6
Affiliation:
[1] Fed Univ Sao Carlos UFSCar, Dept Phys Educ, BR-13565905 Sao Carlos, SP - Brazil
[2] Fed Univ Sao Carlos UFSCar, Dept Gerontol, BR-13565905 Sao Carlos, SP - Brazil
[3] Univ Sao Paulo, Lab Biochem & Mol Biol Exercise, BR-05508030 Sao Paulo, SP - Brazil
[4] Univ Estadual Campinas, UNICAMP, Lab Mol Biol Exercise LaBMEx, Sch Appl Sci, BR-13484350 Limeira, SP - Brazil
Total Affiliations: 4
Document type: Review article
Source: CELLS; v. 8, n. 12 DEC 2019.
Web of Science Citations: 0
Abstract

Recent studies have investigated the control of adipose tissue expansion and inflammatory process by microRNAs (miRNAs). These two processes are of great interest because both are associated with obesity and metabolic syndrome. However, despite the great relevance of the role of miRNAs in obesity and adipose tissue, no qualitative and quantitative analysis on the subject has been performed. Thus, we aimed to examine global research activity and current trends with respect to the interaction between obesity, adipose tissue and miRNAs through a bibliometric analysis. This research was performed on the Scopus database for publications containing miRNA, obesity, and adipose tissue keyword combinations. In total, 898 articles were analyzed and the most frequently occurring keywords were selected and clustered into three well-defined groups. As a result, first group of keywords pointed to the research area on miRNAs expressed in obesity-associated diseases. The second group demonstrated the regulation of the adipogenesis process by miRNAs, while the third group highlighted brown adipose tissue and thermogenesis as one of the latest global research trends related to the theme. The studies selected in this paper describe the expression and performance of different miRNAs in obesity and comorbidities. Most studies have focused on identifying miRNAs and signaling pathways associated with obesity, type 2 diabetes mellitus, and cardiovascular disease. Thus, the miRNA profile for these diseases may be used as biomarkers and therapeutic targets in the prevention and treatment of obesity-associated diseases. (AU)

FAPESP's process: 17/19504-0 - Evaluation of the activity of ruthenium complexes encapsulated in triple-negative breast tumor metastases
Grantee:Ramon Handerson Gomes Teles
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 17/09602-4 - LONGITUDINAL STUDY OF METABOLIC AND PHYSIOLOGICAL MARKERS IN THE DEVELOPMENT OF OBESITY AND METABOLIC SYNDROME IN RATS FED WITH HYPERLIPIDIC DIETS
Grantee:Ana Cláudia Garcia de Oliveira Duarte
Support Opportunities: Regular Research Grants