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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

CYP3A5{*}3 and CYP2C8{*}3 variants influence exposure and clinical outcomes of tacrolimus-based therapy

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Genvigir, Fabiana Dalla Vecchia [1] ; Brayan Campos-Salazar, Antony [1, 2] ; Felipe, Claudia Rosso [3] ; Tedesco-Silva Jr, Helio ; Medina-Pestana, Jose Osmar [4] ; Doi, Sonia de Quateli [5] ; Cerda, Alvaro [6] ; Hirata, Mario Hiroyuki [1] ; Herrero, Maria Jose [7, 8] ; Alino, Salvador Francisco [7, 8] ; Crespo Hirata, Rosario Dominguez [1]
Total Authors: 11
Affiliation:
[1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo - Brazil
[2] Univ Nacl Mayor San Marcos, Sch Pharm & Biochem, Bioinformat & Pharmacogenet Lab, METOSMOD Res Grp, Lima - Peru
[3] Univ Fed Sao Paulo, Hosp Rim, Nephrol Div, Sao Paulo - Brazil
[4] Tedesco-Silva Jr, Jr., Helio, Univ Fed Sao Paulo, Hosp Rim, Nephrol Div, Sao Paulo - Brazil
[5] Uniformed Serv Univ Hlth Sci, Sch Med, Nephrol Res Lab, Bethesda, MD - USA
[6] Univ La Frontera, Ctr Excellence Translat Med, Dept Basic Sci, BIOREN, Temuco - Chile
[7] Univ Valencia Pharmacogenet, Inst Invest Sanitaria, Dept Pharmacol, Valencia - Spain
[8] Hosp La Fe, Valencia - Spain
Total Affiliations: 8
Document type: Journal article
Source: PHARMACOGENOMICS; v. 21, n. 1, p. 7-21, JAN 2020.
Web of Science Citations: 0
Abstract

Aim: The influence of variants in pharmacokinetics-related genes on long-term exposure to tacrolimus (TAC)-based therapy and clinical outcomes was investigated. Patients \& methods: Brazilian kidney recipients were treated with TAC combined with everolimus (n = 178) or mycophenolate sodium (n = 97). The variants in CYP2C8, CYP2J2, CYP3A4, CYP3A5, POR, ABCB1, ABCC2, ABCG2, SLCO1B1 and SLCO2B1 were analyzed. Main results:CYP3A5{*}3/{*}3 genotype influenced increase in TAC concentration from week 1 to month 6 post-transplantation (p < 0.05). The living donor and CYP2C8{*}3 variant were associated with reduced risk for delayed graft function (OR = 0.07; 95% CI = 0.03-0.18 and OR = 0.45; 95% CI = 0.20-0.99, respectively, p < 0.05). Conclusion: The CYP3A5{*}3 variant is associated with increased early exposure to TAC. Living donor and CYP2C8{*}3 variant seem to be protective factors for delayed graft function in kidney recipients. (AU)

FAPESP's process: 16/13118-8 - Pharmacogenomics and epigenomics factors associated with response to immunosuppressive drugs in renal transplant recipients
Grantee:Rosario Dominguez Crespo Hirata
Support type: Regular Research Grants