| Full text | |
| Author(s): Show less - |
Cunha, Marielton dos Passos
[1]
;
Duarte-Neto, Amaro Nunes
[2]
;
Pour, Shahab Zaki
[1]
;
Ortiz-Baez, Ayda Susana
[3, 1, 4]
;
Cerny, Jiri
[5]
;
de Souza Pereira, Barbara Brito
[1]
;
Braconi, Carla Torres
[1]
;
Ho, Yeh-Li
[6]
;
Perondi, Beatriz
[7]
;
Sztajnbok, Jaques
[8]
;
Ferreira Alves, Venancio Avancini
[2]
;
Dolhnikoff, Marisa
[2]
;
Holmes, Edward C.
[3, 9]
;
Nascimento Saldiva, Paulo Hilario
[2]
;
de Andrade Zanotto, Paolo Marinho
[1, 10]
Total Authors: 15
|
| Affiliation: | [1] Univ Sao Paulo, Biomed Sci Inst, Dept Microbiol, Lab Mol Evolut & Bioinformat, Sao Paulo - Brazil
[2] Univ Sao Paulo, Clin Hosp, Fac Med, Pathol Dept, Sao Paulo - Brazil
[3] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006 - Australia
[4] Univ Sydney, Charles Perkins Ctr, Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006 - Australia
[5] Czech Univ Life Sci Prague, Fac Trop AgriSci, Prague - Czech Republic
[6] Univ Sao Paulo, Clin Hosp, Fac Med, Intens Care Unit, Div Clin Infect & Parasit Dis, Sao Paulo - Brazil
[7] Univ Sao Paulo, Clin Hosp, Fac Med, Yellow Fever Crisis Comm, Sao Paulo - Brazil
[8] Inst Infectol Emilio Ribas, Sao Paulo - Brazil
[9] Univ Sydney, Sch Life & Environm Sci, Sydney, NSW - Australia
[10] Sci Platform Pasteur USP, Sao Paulo - Brazil
Total Affiliations: 10
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 9, DEC 31 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
The largest outbreak of yellow fever of the 21st century in the Americas began in 2016, with intense circulation in the southeastern states of Brazil, particularly in sylvatic environments near densely populated areas including the metropolitan region of Sao Paulo city (MRSP) during 2017-2018. Herein, we describe the origin and molecular epidemiology of yellow fever virus (YFV) during this outbreak inferred from 36 full genome sequences taken from individuals who died following infection with zoonotic YFV. Our analysis revealed that these deaths were due to three genetic variants of sylvatic YFV that belong the South American I genotype and that were related to viruses previously isolated in 2017 from other locations in Brazil (Minas Gerais, Espirito Santo, Bahia and Rio de Janeiro states). Each variant represented an independent virus introduction into the MRSP. Phylogeographic and geopositioning analyses suggested that the virus moved around the peri-urban area without detectable human-to-human transmission, and towards the Atlantic rain forest causing human spill-over in nearby cities, yet in the absence of sustained viral transmission in the urban environment. (AU) | |
| FAPESP's process: | 17/23281-6 - The use of antibodies that neutralize infection at a post-attachment step for the development of innovative immunotherapeutic strategies exemplified for selective destruction of Zika-infected human cells. |
| Grantee: | Paolo Marinho de Andrade Zanotto |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/25434-3 - Intra-host genetic diversity of Dengue virus type 4 strains from the municipality of Guarujá, São Paulo |
| Grantee: | Ayda Susana Ortiz Baez |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 13/21728-2 - The use of modern autopsy techniques to investigate human diseases (MODAU) |
| Grantee: | Paulo Hilário Nascimento Saldiva |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 16/08204-2 - Genetic and phylodynamics diversity of emerging and re-emerging arboviruses (DENV, ZIKV and CHIKV) in the Northeast and Southeast regions of Brazil, 2014-2016 |
| Grantee: | Marielton dos Passos Cunha |
| Support Opportunities: | Scholarships in Brazil - Doctorate |