Effect of Pluronic F127 on the 3D pore morphology of poly(N-isopropylacrylamide-co-acrylic acid) hydrogels and their nitric oxide release from S-nitrosoglutathione

Author(s)

Cabrini, Flavia Mesquita ^[1] ; Champeau, Mathilde ^[2] ; de Oliveira, Marcelo Ganzarolli ^[1]

Affiliation

^[1] Univ Estadual Campinas, UNICAMP, Inst Chem, BR-13083970 Campinas, SP - Brazil

^[2] Fed Univ ABC, Ctr Engn Modeling & Appl Social Sci, Santo Andre, SP - Brazil

• Document type: Journal article
• Source: Journal of Applied Polymer Science; v. 137, n. 36 FEB 2020.
• Web of Science Citations: 0

Abstract

Changing the pore morphology of hydrogels can be an effective strategy to modulate their drug release profiles. Herein, Pluronic F127 was used to change the three-dimensional pore morphology of crosslinked poly(N-isopropylacrylamide-co-acrylic acid) (P{[}NIPAm-co-AAc]) hydrogels. F127 reduced the pore diameters from 20 +/- 4 to 2.9 +/- 0.4 mu m and from 11 +/- 1 to 1.4 +/- 0.4 mu m in hydrogels synthesized at 8 and 30 degrees C, respectively. Small-angle X-ray scattering indicates that the segregation of the F127 during the polymerization process induces F127 phase transitions from unimers (at 8 degrees C) or cubic-packed micelles (at 30 degrees C) to a lamellar structure. P(NIPAm-co-AAc) hydrogels charged with S-nitrosoglutathione (GSNO), released nitric oxide (NO) spontaneously during hydration. The decrease in the pore diameter led to a twofold to threefold increase in the rate of water absorption and a fourfold to sixfold increase in the rate of NO release of the hydrogels. F127 can be used to change the pore morphology of P(NIPAm-co-AAc) hydrogels, with concomitant changes in their rate of hydration and NO release from GSNO, opening a new perspective for their use in topical NO delivery. (AU)

• FAPESP's process: 16/02414-5 - Topical and absorbable biomaterials for the local nitric oxide release
• Grantee: Marcelo Ganzarolli de Oliveira
• Support Opportunities: Research Projects - Thematic Grants