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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Palladium(II) complexes bearing thiosemicarbazone and phosphines as inhibitors of DNA-Topoisomerase II enzyme: Synthesis, characterizations and biological studies

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Author(s):
Lima, Mauro Almeida [1] ; Costa, Vinicius A. [1] ; Franco, Mariane Aralijo [1] ; de Oliveira, Gabriela P. [1] ; Deflon, Victor M. [2] ; Rocha, Fillipe Vieira [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Inst Quim Sao Carlos, Ave Trabalhador Sao Carlense 400, BR-13566590 Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Inorganic Chemistry Communications; v. 112, FEB 2020.
Web of Science Citations: 1
Abstract

Four new palladium(II) complexes bearing thiosemicarbazone and phosphines as ligands were synthesized and fully characterized by IR, NMR, UV-Vis spectroscopies, elemental analysis and X-ray diffraction. The metal complexes were tested towards five cell lines, including, tumor and non-tumor cells. Cytotoxicity of the palladium(II) complexes overcame cisplatin. Compounds did not interacted with the DNA. However, palladium(II) complexes showed an inhibition of action of the Topoisomerase II enzyme at lower concentrations than did etoposide, a standard drug. (AU)

FAPESP's process: 19/11242-1 - Relative quantification of DNA-Topoisomerases enzymes in cell lines: Correlation between cytotoxicity and mechanism of action of coordination compounds
Grantee:Fillipe Vieira Rocha
Support type: Regular Research Grants
FAPESP's process: 16/04201-9 - Transition metal compounds bearinhg thiosemicarbazones and phosphines as ligand: investigation of cytotoxicity and mechanism of action
Grantee:Fillipe Vieira Rocha
Support type: Regular Research Grants