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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The potential contribution of stromal cell-derived factor 2 (SDF2) in endoplasmic reticulum stress response in severe preeclampsia and labor-onset

Full text
Author(s):
Lorenzon-Ojea, Aline R. [1] ; Yung, Hong Wa [2] ; Burton, Graham J. [2] ; Bevilacqua, Estela [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Sao Paulo, SP - Brazil
[2] Univ Cambridge, Dept Physiol Dev & Neurosci, Dept Physiol, Cambridge - England
Total Affiliations: 2
Document type: Review article
Source: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE; v. 1866, n. 2 FEB 1 2020.
Web of Science Citations: 1
Abstract

Endoplasmic reticulum (ER) stress occurs when the protein folding machinery in the cell is unable to cope with newly synthesized proteins, which results in an accumulation of misfolded proteins in the ER lumen. In response, the cell activates a cellular signaling pathway known as the Unfolded Protein Response (UPR), aiming to restore cellular homeostasis. Activation and exacerbation of the UPR have been described in several human pathologies, including cancer and neurological disorders, and in some gestational diseases such as preeclampsia and gestational diabetes. This review explores the participation of stromal cell-derived factor 2 (SDF2) in UPR pathways, shows new information and discusses its exacerbation regarding protein expression in severe preeclampsia and labor, both of which are associated with ER stress. (AU)

FAPESP's process: 16/04210-8 - Sdf2 factor in the activation of the Unfolded Protein Response (UPR) signaling network in the trophoblast physiology and pathology
Grantee:Estela Maris Andrade Forell Bevilacqua
Support Opportunities: Regular Research Grants
FAPESP's process: 17/06824-6 - Expression of Sdf2 in human placenta from preeclamptic and gestational diabetic patients
Grantee:Aline Rodrigues Lorenzon
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 14/13052-1 - The role of Sdf2 (stromal cell derived factor 2) in cell survival/apoptosis of trophoblast cells via endoplasmic reticulum stress
Grantee:Aline Rodrigues Lorenzon
Support Opportunities: Scholarships in Brazil - Post-Doctorate