Tanaka, Leonardo Y.
Oliveira, Percillia V. S.
Laurindo, Francisco R. M.
Total Authors: 3
 Univ Sao Paulo, LIM 64 Translat Cardiovasc Biol, Inst Coracao InCor, Hosp Clin HCFMUSP, Fac Med, Vasc Biol Lab, Ave Eneas C Aguiar 44 Annex 2, 9th Floor, BR-05403904 Sao Paulo - Brazil
Total Affiliations: 1
Antioxidants & Redox Signaling;
Web of Science Citations:
Recent Advances: pecTOR redox-modulates several targets including integrins, ECM proteins, surface molecules, and plasma components, although clear-cut documentation of direct effects is lacking in many cases. TOR catalytic pathways, displaying common patterns, culminate in substrate thiol reduction, oxidation, or isomerization. Peroxiredoxins act as redox/peroxide sensors, contrary to PDIs, which are likely substrate-targeted redox modulators. Emerging evidence suggests important pecTOR roles in patho(physio)logical processes, including blood coagulation, vascular remodeling, mechanosensing, endothelial function, immune responses, and inflammation. Critical Issues: Effects of pecPDIs supporting thrombosis/platelet activation have been well documented and reached the clinical arena. Roles of pecPDIA1 in vascular remodeling/mechanosensing are also emerging. Extracellular thioredoxin and pecPDIs redox-regulate immunoinflammation. Routes of TOR externalization remain elusive and appear to involve Golgi-independent routes. pecTORs are particularly accessible drug targets. Future Directions: Further understanding mechanisms of thiol redox reactions and developing assays for assessing pecTOR redox activities remain important research avenues. Also, addressing pecTORs as disease markers and achieving more efficient/specific drugs for pecTOR modulation are major perspectives for diagnostic/therapeutic improvements. (AU)