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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Surveillance of human retroviruses in blood samples from patients with hepatitis B and C in São Paulo, Brazil

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Author(s):
Caterino-de-Araujo, Adele [1] ; Compos, Karoline Rodrigues [1] ; Boas Petrucci, Tamirez Villas [1] ; da Silva, Rafael Xavier [1] ; Lemos, Marcilio Figueiredo [2] ; Moreira, Regina Celia [2]
Total Authors: 6
Affiliation:
[1] Secretaria Estado Saude Sao Paulo, Lab Pesquisa HTLV, Ctr Imunol, Inst Adolfo Lutz, Controle Doencas, Sao Paulo, SP - Brazil
[2] Secretaria Estado Saude Sao Paulo, Lab Hepatites, Ctr Virol, Inst Adolfo Lutz, Controle Doencas, Nucleo Doencas, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Revista da Sociedade Brasileira de Medicina Tropical; v. 53, 2020.
Web of Science Citations: 2
Abstract

Abstract INTRODUCTION Human retroviruses and the hepatitis B and C viruses (HBV and HCV, respectively) share routes of transmission; thus, coinfections occur and could alter subsequent disease outcomes. A preliminary study on human T-lymphotropic virus types 1 and 2 (HTLV-1/2) in serum samples from HBV- and HCV-infected individuals in São Paulo revealed 1.3% and 5.3% rates of coinfection, respectively. These percentages were of concern since they were detected in HTLV-endemic regions and in high-risk individuals in Brazil. The present study was conducted to extend and confirm these data. METHODS HTLV-1/2 and human immunodeficiency virus (HIV) infection status were identified in 1,984 sera for HBV and HCV viral load quantification - 1,290 samples from HBV-infected individuals (53.3% men, mean age: 47.1 years) and 694 samples from HCV-infected individuals (56.3% men, mean age: 50.1 years). HTLV-1/2 antibodies were detected by enzyme immunoassay, followed by western blotting and line immunoassay; HIV infection was detected by enzyme immunoassay. RESULTS HTLV-1/-2 infection was detected in 1.9% HBV-infected individuals (0.7% HTLV-1 and 1.2% HTLV-2) and in 4.0% (2.4% HTLV-1 and 1.6% HTLV-2) HCV-infected individuals; HIV infection was detected in 9.2% and 14.5%, respectively. Strong associations with HTLV and HIV, male sex, and older age were found in HBV/HTLV and HCV/HTLV-coinfected individuals (p<0.05). CONCLUSIONS HTLV-1 and HTLV-2 were confirmed to be prevalent in individuals with HBV and HCV in São Paulo; coinfected individuals deserve further clinical and laboratory investigation. (AU)

FAPESP's process: 16/03654-0 - Host and virus genetic markers that influenced the course of the HIV-1, HIV-1/HTLV-1 and HIV-1/HTLV-2 coinfections
Grantee:Adele Caterino de Araújo
Support Opportunities: Regular Research Grants