Evaluation of COLIA1-1997 G/T polymorphism as a related factor to genital prolapse

Author(s)

Palos, Claudia Cristina ^[1] ; Timm, Beatriz Ferreira ^[2] ; Paulo, Denise de Souza ^[1] ; Fernandes, Cesar Eduardo ^[1] ; de Souto, Ricardo Peres ^[2] ; Oliveira, Emerson ^[1]

Affiliation

^[1] ABC Med Sch, Discipline Gynecol, Dept Urogynecol & Vaginal Surg, Santo Andre, SP - Brazil

^[2] ABC Med Sch, Dept Morphol & Physiol, Santo Andre, SP - Brazil

• Document type: Journal article
• Source: INTERNATIONAL UROGYNECOLOGY JOURNAL; v. 31, n. 1, p. 133-137, JAN 2020.
• Web of Science Citations: 0

Abstract

Introduction and hypothesis Pelvic organ prolapse has a multifactorial etiology. There is increasing evidence that genetic factors greatly impact its development. This study aimed to evaluate the possible relation of the collagenous polymorphism -1997 G/T with genital prolapse in Brazilian women. Methods A cohort study of 180 women with stage 0 or I (group A) pelvic organ prolapse disorder and 112 women with stage III or IV (group B) was conducted. Blood DNA was isolated, and the -1997 G/T polymorphism was identified by amplifying a region of the COLIA1 gene starting prior to the protein's coding sequence. Results No significant difference in the prevalence of genotypes TG and TT was found between groups (p = 0.67); differences were not found even when patients were grouped by the presence of 0 or >= 1 polymorphic alleles (p = 0.46). Age and home birth were found to be independent risk factors for prolapse. Conclusions Our study could not find any association between the -1997G/T polymorphism and genital prolapse in Brazilian women. (AU)

• FAPESP's process: 14/01107-6 - Analysis of polymorphisms of genes responsible for the biosynthesis and metabolism of collagen as risk factors for development of genital prolapse
• Grantee: Emerson de Oliveira
• Support Opportunities: Regular Research Grants