Environmental Tobacco Smoke During the Early Postnatal Period of Mice Interferes With Brain (18) F-FDG Uptake From Infancy to Early Adulthood - A Longitudinal Study

Author(s):Show less -

Torres, Larissa Helena ^{[1, 2]} ; Real, Caroline Cristiano ^[3] ; Turato, Walter Miguel ^[1] ; Spelta, Lidia Wiazowski ^[1] ; Cardoso dos Santos Durao, Ana Carolina ^[1] ; Andrioli, Tatiana Costa ^[1] ; Pozzo, Lorena ^[4] ; Squair, Peterson Lima ^[4] ; Pistis, Marco ^{[5, 6]} ; Faria, Daniele de Paula ^[3] ; Marcourakis, Tania ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Sao Paulo - Brazil

^[2] Univ Fed Alfenas, Fac Ciencias Farmacut, Dept Alimentos & Medicamentos, Alfenas - Brazil

^[3] Univ Sao Paulo, Lab Nucl Med LIM 43, Dept Radiol & Oncol, Fac Med, Sao Paulo - Brazil

^[4] Inst Pesquisas Energet & Nucl, Sao Paulo - Brazil

^[5] Univ Cagliari, Fac Med & Surg, Dept Biomed Sci, Cagliari - Italy

^[6] Univ Cagliari, Fac Med & Surg, CNR Inst Neurosci, Cagliari - Italy

• Document type: Journal article
• Source: FRONTIERS IN NEUROSCIENCE; v. 14, JAN 29 2020.
• Web of Science Citations: 0

Abstract

Exposure to environmental tobacco smoke (ETS) is associated with high morbidity and mortality, mainly in childhood. Our aim was to evaluate the effects of postnatal ETS exposure in the brain 2-deoxy-2-{[}F-18]-fluoro-D-glucose (F-18-FDG) uptake of mice by positron emission tomography (PET) neuroimaging in a longitudinal study. C57BL/6J mice were exposed to ETS that was generated from 3R4F cigarettes from postnatal day 3 (P3) to P14. PET analyses were performed in male and female mice during infancy (P15), adolescence (P35), and adulthood (P65). We observed that ETS exposure decreased F-18-FDG uptake in the whole brain, both left and right hemispheres, and frontal cortex in both male and female infant mice, while female infant mice exposed to ETS showed decreased F-18-FDG uptake in the cerebellum. In addition, all mice showed reduced F-18-FDG uptake in infancy, compared to adulthood in all analyzed VOIs. In adulthood, ETS exposure during the early postnatal period decreased brain F-18-FDG uptake in adult male mice in the cortex, striatum, hippocampus, cingulate cortex, and thalamus when compared to control group. ETS induced an increase in F-18-FDG uptake in adult female mice when compared to control group in the brainstem and cingulate cortex. Moreover, male ETS-exposed animals showed decreased F-18-FDG uptake when compared to female ETS-exposed in the whole brain, brainstem, cortex, left amygdala, striatum, hippocampus, cingulate cortex, basal forebrain and septum, thalamus, hypothalamus, and midbrain. The present study shows that several brain regions are vulnerable to ETS exposure during the early postnatal period and these effects on F-18-FDG uptake are observed even a long time after the last exposure. This study corroborates our previous findings, strengthening the idea that exposure to tobacco smoke in a critical period interferes with brain development of mice from late infancy to early adulthood. (AU)

• FAPESP's process: 13/12769-7 - Exposure to environmental tobacco smoke during early postnatal period in rodents: implications for synaptic plasticity and the endocannabinoid system.
• Grantee: Larissa Helena Lobo Torres Pacheco
• Support Opportunities: Scholarships in Brazil - Post-Doctorate