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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Afferent innervation of the ischemic kidney contributes to renal dysfunction in renovascular hypertensive rats

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Lopes, Nathalia R. [1] ; Milanez, Maycon I. O. [1] ; Martins, Beatriz S. [1] ; Veiga, Amanda C. [1] ; Ferreira, Giovanna R. [1] ; Gomes, Guiomar N. [1] ; Girardi, Adriana C. [2] ; Carvalho, Polliane M. [3] ; Nogueira, Fernando N. [3] ; Campos, Ruy R. [1] ; Bergamaschi, Cassia T. [1] ; Nishi, Erika E. [1, 4]
Total Authors: 12
[1] Univ Fed Sao Paulo, Dept Physiol, Escola Paulista Med, EPM, UNIFESP, Sao Paulo - Brazil
[2] Univ Sao Paulo, Heart Inst InCor, Med Sch, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Dent Fac, Dept Biomat & Oral Biol, Sao Paulo, SP - Brazil
[4] Univ Fed Sao Paulo, Dept Physiol, Cardiovasc & Resp Physiol Div, EPM, UNIFESP, Rua Botucatu 862, BR-04023060 Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Web of Science Citations: 1

The ablation of renal nerves, by destroying both the sympathetic and afferent fibers, has been shown to be effective in lowering blood pressure in resistant hypertensive patients. However, experimental studies have reported that the removal of sympathetic fibers may lead to side effects, such as the impairment of compensatory cardiorenal responses during a hemodynamic challenge. In the present study, we evaluated the effects of the selective removal of renal afferent fibers on arterial hypertension, renal sympathetic nerve activity, and renal changes in a model of renovascular hypertension. After 4 weeks of clipping the left renal artery, afferent renal denervation (ARD) was performed by exposing the left renal nerve to a 33 mM capsaicin solution for 15 min. After 2 weeks of ARD, we found reduced MAP (18%) and sympathoexcitation to both the ischemic and contralateral kidneys in the hypertensive group. Moreover, a reduction in reactive oxygen species was observed in the ischemic (76%) and contralateral (27%) kidneys in the 2K1C group. In addition, ARD normalized renal function markers and proteinuria and podocin in the contralateral kidney. Taken altogether, we show that the selective removal of afferent fibers is an effective method to reduce MAP and improve renal changes without compromising the function of renal sympathetic fibers in the 2K1C model. Renal afferent nerves may be a new target in neurogenic hypertension and renal dysfunction. (AU)

FAPESP's process: 18/02671-3 - Functional and molecular actions of renal nerve in experimental chronic renal failure
Grantee:Cassia Marta de Toledo Bergamaschi
Support type: Regular Research Grants
FAPESP's process: 15/23858-6 - Effects of renal denervation on renal oxidative stress in experimental renovascular hypertension
Grantee:Nathalia Rodrigues Lopes
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 17/12383-2 - Evaluation of cardiovascular and renal effects of selective denervation of renal afferents in 2 kidney, 1 clip wistar rats
Grantee:Nathalia Rodrigues Lopes
Support type: Scholarships in Brazil - Master
FAPESP's process: 16/22140-7 - Molecular bases of renal tubular function and dysfunction
Grantee:Adriana Castello Costa Girardi
Support type: Research Projects - Thematic Grants