| Full text | |
| Author(s): |
Lazarini-Lopes, Willian
[1, 2]
;
Do Val-da Silva, Raquel A.
[1]
;
da Silva-Junior, Rui M. P.
[2]
;
Leite, Joao P.
[1]
;
Garcia-Cairasco, Norberto
[1, 2]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Ribeirao Preto Sch Med, Neurosci & Behav Sci Dept, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Sch Med, Physiol Dept, Neurophysiol & Expt Neuroethol Lab, Ave Bandeirantes 3900, BR-14049900 Ribeirao Preto - Brazil
Total Affiliations: 2
|
| Document type: | Review article |
| Source: | NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS; v. 111, p. 166-182, APR 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Epilepsy is a neurological disorder characterized by the presence of seizures and neuropsychiatric comorbidities. Despite the number of antiepileptic drugs, one-third of patients did not have their seizures under control, leading to pharmacoresistance epilepsy. Cannabis sativa has been used since ancient times in Medicine for the treatment of many diseases, including convulsive seizures. In this context, Cannabidiol (CBD), a non-psychoactive phytocannabinoid present in Cannabis, has been a promising compound for treating epilepsies due to its anticonvulsant properties in animal models and humans, especially in pharmacoresistant patients. In this review, we summarize evidence of the CBD anticonvulsant activities present in a great diversity of animal models. Special attention was given to behavioral CBD effects and its translation to human epilepsies. CBD anticonvulsant effects are associated with a great variety of mechanisms of action such as endocannabinoid and calcium signaling. CBD has shown effectiveness in the clinical scenario for epilepsies, but its effects on epilepsy-related comorbidities are scarce even in basic research. More detailed and complex behavioral evaluation about CBD effects on seizures and epilepsy-related comorbidities are required. (AU) | |
| FAPESP's process: | 19/05957-8 - Epilepsies and neuropsyquiatric comorbidities: characterization of the effects of the treatment with cannabidiol and HUF-101 in in vivo and in vitro experimental models |
| Grantee: | Norberto Garcia Cairasco |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/50891-1 - INCT 2014: Translational Medicine |
| Grantee: | Jaime Eduardo Cecilio Hallak |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 19/00849-2 - Uncovering pathophysiological and molecular mechanisms involved in tumorigenesis by platforms for next-generation sequencing (NGS) |
| Grantee: | Rui Milton Patrício da Silva Junior |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |