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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mitochondrially-targeted treatment strategies

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Author(s):
Bozi, Luiz H. M. [1] ; Campos, Juliane C. [1] ; Zambelli, Vanessa O. [2] ; Ferreira, Nikolas D. [1] ; Ferreira, Julio C. B. [1, 3]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo - Brazil
[2] Butantan Inst, Sao Paulo - Brazil
[3] Stanford Univ, Dept Chem & Syst Biol, Sch Med, Stanford, CA 94305 - USA
Total Affiliations: 3
Document type: Review article
Source: MOLECULAR ASPECTS OF MEDICINE; v. 71, FEB 2020.
Web of Science Citations: 0
Abstract

Disruption of mitochondrial function is a common feature of inherited mitochondrial diseases (mitochondriopathies) and many other infectious and non-infectious diseases including viral, bacterial and protozoan infections, inflammatory and chronic pain, neurodegeneration, diabetes, obesity and cardiovascular diseases. Mitochondria therefore become an attractive target for developing new therapies. In this review we describe critical mechanisms involved in the maintenance of mitochondrial functionality and discuss strategies used to identify and validate mitochondrial targets in different diseases. We also highlight the most recent preclinical and clinical findings using molecules targeting mitochondrial bioenergetics, morphology, number, content and detoxification systems in common pathologies. (AU)

FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
Grantee:Ohara Augusto
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 17/16071-5 - Contribution of the Mitocondrial Aldehyde dehydrogenase-2 Enzime on Neuropathic Pain.
Grantee:Vanessa Olzon Zambelli
Support type: Regular Research Grants
FAPESP's process: 18/18627-3 - Mechanisms of exercise-induced mitophagy: a new avenue to drug discovery
Grantee:Julio Cesar Batista Ferreira
Support type: Scholarships abroad - Research
FAPESP's process: 17/24836-1 - Role of autophagy in neurogenic myopathy
Grantee:Nikolas Dresch Ferreira
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 17/16540-5 - EXERCISE, LIFESPAN AND HEALTHSPAN: A MOLECULAR AND LONGITUDINAL APPROACH TO STUDY THEIR INTERACTIONS
Grantee:Juliane Cruz Campos
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/16694-2 - Impact of 4-hydroxinonenal on DICER regulation: a translational approach
Grantee:Julio Cesar Batista Ferreira
Support type: Regular Research Grants
FAPESP's process: 18/19332-7 - ALDH2 enzymatic activity regulates opioid drug tolerance
Grantee:Vanessa Olzon Zambelli
Support type: Scholarships abroad - Research