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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Determination of isotretinoin (13-cis-retinoic acid) using a sensor based on reduced graphene oxide modified with copper nanoparticles

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Fernandes, Victoria Quintas [1] ; Leme Silva, Martin K. [1] ; Cesarino, Ivana [1]
Total Authors: 3
[1] Sao Paulo State Univ, Sch Agr, UNESP, Botucatu, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Web of Science Citations: 0

The electrochemical behaviour of isotretinoin (13-cis-RA) on an electrode modified with a composite based on reduced graphene oxide (rGO) modified with copper nanoparticles (CuNPs) was investigated. The rGO-CuNPs composite was successfully synthesized by a simple chemical reduction step and then characterized by microscopic and electrochemical techniques. The rGO-CuNPs modified glassy carbon (GC) electrode was applied successfully in the direct electrochemical detection of isotretinoin in a 0.2 mol L-1 phosphate buffer solution (PBS - pH 7.0) solution (as the electrolyte). Differential pulse voltammetry (DPV) was the methodology used. The presented method displayed linearity in the concentration range from 02 to 3.0 mu mol L-1 with a limit of detection (LOD) of 15.3 nmol L-1. This is the lowest LOD for isotretinoin reported in the literature using an electroanalytical approach. The proposed sensor was applied in the determination of isotretinoin in synthetic plasmatic serum with a recovery of 91% from the original signal. (C) 2019 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 17/24274-3 - Development of glucose biosensor as an analytical tool aiming the optimization of second-generation ethanol production from pineapple residues
Grantee:Ivana Cesarino
Support type: Program for Research on Bioenergy (BIOEN) - Regular Program Grants
FAPESP's process: 17/08733-8 - Evaluation of the modified graphene-based composite with different metallic nanoparticles in the development of an electrochemical sensor for determination of isotretinoin
Grantee:Victória Quintas Fernandes
Support type: Scholarships in Brazil - Scientific Initiation