| Full text | |
| Author(s): Show less - |
Reis, Aramys S.
[1, 2]
;
Barboza, Renato
[3]
;
Murillo, Oscar
[1]
;
Barateiro, Andre
[1]
;
Peixoto, Erika P. M.
[1]
;
Lima, Flavia A.
[1]
;
Gomes, Vinicius M.
[4]
;
Dombrowski, Jamille G.
[1]
;
Leal, Vinicius N. C.
[5]
;
Araujo, Franciele
[6]
;
Bandeira, Carla L.
[1]
;
Araujo, Rosana B. D.
[1]
;
Neres, Rita
[7]
;
Souza, Rodrigo M.
[1, 8]
;
Costa, Fabio T. M.
[9]
;
Pontillo, Alessandra
[5]
;
Bevilacqua, Estela
[6]
;
Wrenger, Carsten
[1]
;
Wunderlich, Gerhard
[1]
;
Palmisano, Giuseppe
[1]
;
Labriola, Leticia
[4]
;
Bortoluci, Karina R.
[3]
;
Penha-Goncalves, Carlos
[7]
;
Goncalves, Ligia A.
[1]
;
Epiphanio, Sabrina
[10]
;
Marinho, Claudio R. F.
[1]
Total Authors: 26
|
| Affiliation: | [1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, Sao Paulo, SP - Brazil
[2] Univ Fed Maranhao, Fac Med, Ctr Ciencias Sociais, Imperatriz, MA - Brazil
[3] Univ Fed Sao Paulo, Dept Ciencias Biol, Diadema, SP - Brazil
[4] Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, Sao Paulo, SP - Brazil
[6] Univ Sao Paulo, Inst Ciencias Biomed, Dept Biol Celular & Desenvolvimento, Sao Paulo, SP - Brazil
[7] Inst Gulbenkian Ciencias, Oeiras - Portugal
[8] Univ Fed Acre, Ctr Multidisciplinar, Campus Floresta, Cruzeiro Do Sul, AC - Brazil
[9] Univ Estadual Campinas, Inst Biol, Dept Genet Evolucao & Bioagentes, Campinas, SP - Brazil
[10] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Sao Paulo, SP - Brazil
Total Affiliations: 10
|
| Document type: | Journal article |
| Source: | SCIENCE ADVANCES; v. 6, n. 10 MAR 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Placental malaria (PM) is associated with severe inflammation leading to abortion, preterm delivery, and intrauterine growth restriction. Innate immunity responses play critical roles, but the mechanisms underlying placental immunopathology are still unclear. Here, we investigated the role of inflammasome activation in PM by scrutinizing human placenta samples from an endemic area and ablating inflammasome components in a PM mouse model. The reduction in birth weight in babies from infected mothers is paralleled by increased placental expression of AIM2 and NLRP3 inflammasomes. Using genetic dissection, we reveal that inflammasome activation pathways are involved in the production and detrimental action of interleukin-1 beta (IL-1 beta) in the infected placenta. The IL-1R pharmacological antagonist Anakinra improved pregnancy outcomes by restoring fetal growth and reducing resorption in an experimental model. These findings unveil that IL-1 beta-mediated signaling is a determinant of PM pathogenesis, suggesting that IL-1R antagonists can improve clinical outcomes of malaria infection in pregnancy. (AU) | |
| FAPESP's process: | 14/09964-5 - The role of inflammasomes in the pathogenesis of malaria during pregnancy: effects and mechanisms |
| Grantee: | Cláudio Romero Farias Marinho |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/23395-6 - Immunogenetics of the inflammasome and translational study "from bed to bench and back": analysis of variations in inflammasome genes in monogenic and multifactorial autoinflammatory diseases for differential diagnosis and therapeutic applications |
| Grantee: | Alessandra Pontillo |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/20451-0 - The role of endothelial cells in the immunopathogenesis of murine malaria-associated ALI/ARDS: effects and mechanisms |
| Grantee: | Sabrina Epiphanio |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 17/03939-7 - Impact of autophagy and inflammasome on the pathogenesis of Placental Malaria |
| Grantee: | André Filipe Rivais Martins Barateiro |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 11/19048-8 - Role of Inflamassoma in the immunopathogenesis of Placental Malaria |
| Grantee: | Aramys Silva dos Reis |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 17/05782-8 - The study of vascular permeability in the malaria-associated acute respiratory distress syndrome |
| Grantee: | Sabrina Epiphanio |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/16417-8 - Autophagy in placental malaria: effects and mechanisms |
| Grantee: | Flávia Afonso Lima |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 16/07030-0 - Characterization of autophagic activity and inflammasome in placental malaria |
| Grantee: | Cláudio Romero Farias Marinho |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/16525-2 - Plasmodium vivax: pathogenesis and infectivity |
| Grantee: | Fabio Trindade Maranhão Costa |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 12/04755-3 - Association of gestational malaria with intrauterine growth restriction and low birth weight in the far-western Brazilian Amazon |
| Grantee: | Jamille Gregório Dombrowski |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 15/50650-7 - Characterization of novel molecular players in the control of obesity and obesity-induced inflammation |
| Grantee: | Alessandra Pontillo |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/20468-0 - Recrudescence of the malaria during pregnancy: effects and mechanisms |
| Grantee: | Cláudio Romero Farias Marinho |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/00981-1 - Characterization of the role of dendritic cells in the recrudescence of malaria in pregnancy |
| Grantee: | Oscar Javier Murillo Gómez |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 11/17880-8 - Toll-like receptors and NOD-like receptors in pregnancy-associated malaria pathogenesis: effects and mechanisms |
| Grantee: | Renato Barboza |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 15/06106-0 - The role of inflammasomes in the pathogenesis of malaria during pregnancy: effects and mechanisms |
| Grantee: | Cláudio Romero Farias Marinho |
| Support Opportunities: | Research Grants - Visiting Researcher Grant - International |