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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Iron-deficient diet induces distinct protein profile related to energy metabolism in the striatum and hippocampus of adult rats

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Pino, Jessica M. V. [1] ; Nishiduka, Erika S. [1] ; da Luz, Marcio H. M. [1] ; Silva, Vitoria F. [1] ; Antunes, Hanna K. M. [2] ; Tashima, Alexandre K. [1] ; Guedes, Pedro L. R. [2] ; de Souza, Altay A. L. [3] ; Lee, Kil S. [1]
Total Authors: 9
[1] Univ Fed Sao Paulo, Dept Bioquim, 669 Pedro de Toledo St, 8th Floor, BR-04039032 Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Biociencia, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Web of Science Citations: 0

Iron deficiency is a public health problem that affects all age groups. Its main consequence is anemia, but it can also affect cognitive functions. Although the negative effects of iron deficiency on cognitive function have been extensively described, the underlying mechanism has not been fully investigated. Thus, to gain an unbiased insight into the effects of iron deficiency (ID) on discrete brain regions, we performed a proteomic analysis of the striatum and hippocampus of adult rats subjected to an iron restricted (IR) diets for 30 days. We found that an IR diet caused major alterations in proteins related to glycolysis and lipid catabolism in the striatum. In the hippocampus, a larger portion of proteins related to oxidative phosphorylation and neurodegenerative diseases were altered. These alterations in the striatum and hippocampus occurred without a reduction in local iron levels, although there was a drastic reduction in liver iron and ferritin. Moreover, the IR group showed higher fasting glycaemia than the control group. These results suggest that brain iron content is preserved during acute iron deficiency, but the alterations of other systemic metabolites such as glucose may trigger distinct metabolic adaptations in each brain region. Abnormal energy metabolism precedes and persists in many neurological disorders. Thus, altered energy metabolism can be one of the mechanisms by which iron deficiency affects cognitive functions. (AU)

FAPESP's process: 17/20106-9 - Peptidomics of Brazilian snake and spider venoms
Grantee:Alexandre Keiji Tashima
Support type: Regular Research Grants
FAPESP's process: 16/04297-6 - Impacts of nutrition and sleep on expression, solubility and functions of neural proteins.
Grantee:Kil Sun Lee
Support type: Regular Research Grants