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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Electrochemical quartz crystal microbalance with dissipation investigation of fibronectin adsorption dynamics driven by electrical stimulation onto a conducting and partially biodegradable copolymer

Full text
Author(s):
da Silva, Arua C. [1] ; da Silva, Rubens A. [1] ; Souza, Maria J. P. G. [1] ; Montoya, Paula M. [2] ; Bentini, Ricardo [1] ; Augusto, Tatiana [1] ; Torresi, Roberto M. [1] ; Catalani, Luiz H. [1] ; de Torresi, Susana I. Cordoba [1]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, Ave Prof Lineu Prestes 748, CP 26077, BR-05508000 Sao Paulo - Brazil
[2] Univ Antioquia UdeA, Ctr Invest Innovac & Desarrollo Mat CIDEMAT, Calle 70 52-21, Medellin 1226 - Colombia
Total Affiliations: 2
Document type: Journal article
Source: BIOINTERPHASES; v. 15, n. 2 MAR 2020.
Web of Science Citations: 0
Abstract

Functional surface coatings are a key option for biomedical applications, from polymeric supports for tissue engineering to smart matrices for controlled drug delivery. Therefore, the synthesis of new materials for biological applications and developments is promising. Hence, biocompatible and stimuli-responsive polymers are interesting materials, especially when they present conductive properties. PEDOT-co-PDLLA graft copolymer exhibits physicochemical and mechanical characteristics required for biomedical purposes, associated with electroactive, biocompatible, and partially biodegradable properties. Herein, the study of fibronectin (FN) adsorption onto PEDOT-co-PDLLA carried out by an electrochemical quartz crystal microbalance with dissipation is reported. The amount of FN adsorbed onto PEDOT-co-PDLLA was higher than that adsorbed onto the Au surface, with a significant increase when electrical stimulation was applied (either at +0.5 or -0.125 V). Additionally, FN binds to the copolymer interface in an unfolded conformation, which can promote better NIH-3T3 fibroblast cell adhesion and later cell development. (AU)

FAPESP's process: 18/13492-2 - Synthetic and natural scaffolds applied to regenerative medicine
Grantee:Luiz Henrique Catalani
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 17/08349-3 - Evaluation of the adhesion and proliferation processes of cellular in PEDOT-co-PDLLA thin films supported on Au electrodes functionalized with laminin, integrin and fibronectin
Grantee:Rubens Araujo da Silva
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 15/26308-7 - Optimization of the physicochemical properties of nano -structured materials for applications in molecular recognition, catalysis and energy conversion/storage
Grantee:Roberto Manuel Torresi
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 17/00705-5 - Study of interaction between different proteins with a PEDOT-co-PLLA surface by EC-AFM
Grantee:Aruã Clayton da Silva
Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)
FAPESP's process: 14/09353-6 - Biomaterials based on conducting biodegradable and biocompatible polymers
Grantee:Aruã Clayton da Silva
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)