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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Higher increase degree of FGF21 post long-term interdisciplinary weight loss therapy preserves the free fat mass and rest metabolic rate in adolescents with obesity

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Ana Claudia Pelissari Kravchychyn ; Raquel Munhoz da Silveira Campos ; Yasmin Alaby Martins Ferreira ; Sofia Emanuelle de Castro Ferreira Vicente ; Flávia Campos Corgosinho ; Lila Missae Oyama ; David Thivel ; Lian Tock ; Ana Raimunda Dâmaso
Total Authors: 9
Document type: Journal article

ABSTRACT Objective Fibroblast growth factor 21 (FGF21) is among the activators that can stimulate thermogenesis in the white adipose tissue and brown adipose tissue. People with obesity have elevated blood levels of FGF21, but also develop resistance to its action, impairing its beneficial role. Inversely, clinical treatments to weight loss has been pointed out as an important therapy for increasing and recovering sensitivity to FGF21. The aim was to analyse the effect of long-term weight loss interdisciplinary intervention on FGF21 and body composition. Subjects and methods Eighty-six post-pubertal obese adolescents (14-19 years-old), were submitted to 20 weeks of weight loss therapy (clinical, nutritional, psychological and physical exercise support). Anthropometric measures, body composition and rest metabolic rate (RMR) by bioelectrical impedance, and serum FGF21 sample by ELISA were evaluated. The adolescents were grouped according to FGF21 individual delta variations after therapy: Higher Increase (HI); lower increase (LI); lower decrease (LD); higher decrease (HD). Results All groups present weight loss. Only in FGF21 ≥ 76,5 pg/mL variation the free-fat-mass and rest metabolic rate were preserved and to others group these variables were significantly reduced. Conclusion High increase in FGF21 can contribute to preservation of FFM and RMR after weight loss therapy, could have important implications for energy balance regulation. Future studies are necessary to continue determining the role of magnitude effects of FGF21 levels in obesity to improve clinical practice, especially in paediatrics population. (AU)

FAPESP's process: 15/14309-9 - Effects of physical exercise associate with phototherapy on adipogenesis biomarkers and transdifferentiation of adipose tissue in adult obese women
Grantee:Raquel Munhoz da Silveira Campos
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/08522-6 - New therapeutic perspectives in obesity
Grantee:Ana Raimunda Dâmaso
Support type: Regular Research Grants
FAPESP's process: 11/50414-0 - Influence of hyperleptinemia on inflammatory and atherogenic responses in obese adolescents
Grantee:Ana Raimunda Dâmaso
Support type: Regular Research Grants