Systematic Analysis of Monoterpenes: Advances and Challenges in the Treatment of Peptic Ulcer Diseases

Author(s)

Perico, Larissa Lucena ^[1] ; Emilio-Silva, Maycon Tavares ^[1] ; Ohara, Rie ^[1] ; Rodrigues, Vinicius Peixoto ^[1] ; Bueno, Gabriela ^[1] ; Barbosa-Filho, Jose Maria ^[2] ; Rocha, Lucia Regina Machado da ^[1] ; Batista, Leonia Maria ^[2] ; Hiruma-Lima, Clelia Akiko ^[1]

Affiliation

^[1] Sao Paulo State Univ Unesp, Inst Biosci, Dept Physiol, BR-18618970 Botucatu, SP - Brazil

^[2] Univ Fed Paraiba, Hlth Sci Ctr, Dept Pharmaceut Sci, BR-58051900 Joao Pessoa, Paraiba - Brazil

• Document type: Review article
• Source: BIOMOLECULES; v. 10, n. 2 FEB 2020.
• Web of Science Citations: 0

Abstract

Peptic ulcer disease (PUD) is a multifactorial and complex disease caused by an imbalance of protective and aggressive factors (endogenous and exogenous). Despite advances in recent years, it is still responsible for substantial mortality and triggering clinical problems. Over the last decades, the understanding of PUD has changed a lot with the discovery of Helicobacter pylori infection. However, this disease continues to be a challenge due to side-effects, incidence of relapse from use of various anti-ulcer medicines, and the rapid appearance of antimicrobial resistance with current H. pylori therapies. Consequently, there is the need to identify more effective and safe anti-ulcer agents. The search for new therapies with natural products is a viable alternative and has been encouraged. The literature reports the importance of monoterpenes based on the extensive pharmacological action of this class, including wound healing and anti-ulcerogenic agents. In the present study, 20 monoterpenes with anti-ulcerogenic properties were evaluated by assessing recent in vitro and in vivo studies. Here, we review the anti-ulcer effects of monoterpenes against ulcerogenic factors such as ethanol, nonsteroidal anti-inflammatory drugs (NSAIDs), and Helicobacter pylori, highlighting challenges in the field. (AU)

• FAPESP's process: 18/10935-0 - Evaluation of action citral on lipopolysaccharide-induced fever in obese mice with high-fat diet
• Grantee: Maycon Tavares Emílio Silva
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 18/09873-0 - Obesity induced by hypercaloric diet: evaluation of the action of Citral in metabolic inflammation, systemic and healing of gastric ulcers
• Grantee: Clélia Akiko Hiruma Lima
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/14797-3 - The role of the hydroalcoholic extract from the leaves of Eugenia punicifolia (Kunth) DC on experimental peptic ulcer disease: characterization of mechanisms of action anti-inflammatory, healing and antiapoptotic.
• Grantee: Larissa Lucena Périco
• Support Opportunities: Scholarships in Brazil - Doctorate