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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Triclosan toothpaste as an adjunct therapy to plaque control in children from periodontitis families: a crossover clinical trial

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Monteiro, Mabelle Freitas [1] ; Tonelli, Henrique [1] ; Reis, Aurelio Amorim [1] ; Casati, Marcio Zaffalon [1] ; Silverio, Karina Gonzales [1] ; Nociti Junior, Francisco Humberto [1] ; Sallum, Enilson Antonio [1] ; Casarin, Renato Correa Viana [1]
Total Authors: 8
[1] Univ Estadual Campinas, Piracicaba Dent Sch, Div Periodont, Ave Limeira 901, BR-13414903 Piracicaba, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: CLINICAL ORAL INVESTIGATIONS; v. 24, n. 4, p. 1421-1430, APR 2020.
Web of Science Citations: 0

Objectives Studies have demonstrated that children from aggressive periodontitis (AgP) parents presented precocious alterations in their periodontal condition, and the use of chemical agents in association to plaque control could be useful to control these alterations. This study aimed to evaluate the effect of Triclosan toothpaste to modulate the clinical and subgingival condition in children from AgP parents. Methods Fifteen children from AgP parents and 15 from periodontally healthy parents were included in this crossover placebo study. Children were randomly allocated into triclosan or placebo therapy, using selected toothpaste for 45 days. After 15 days of wash-out, groups were crossed, changing the used toothpaste. Clinical examination and saliva, crevicular gingival fluid (GCF), and subgingival biofilm collection were performed at baseline and 45 days of each phase. GCF cytokines' levels were analyzed by Luminex/MAGpix platform and subgingival and salivary periodontal pathogens' levels by qPCR. Results At baseline, AgP group presented higher plaque index (PI), gingival index (GI), and bleeding on probing (BoP), higher Aggregatibacter actinomycetemcomitans (Aa) abundance in saliva and subgingival biofilm, and lower levels of INF-gamma, IL-4, and IL-17 in GCF. Placebo therapy only reduced PI in both groups. Triclosan toothpaste reduced PI and GI in both groups. Triclosan promoted reduction of BoP and probing depth (PD), Aa salivary, and IL-1 beta levels in AgP group. In health group, triclosan reduced INF-gamma and IL-4 concentration. Conclusion Triclosan toothpaste demonstrated to be more effective than placebo toothpaste to control the periodontal condition in children from AgP parents, by reducing the BoP, PD, salivary Aa, and IL-1 beta. Trial registration This study was registered at with the identifier NCT03642353. (AU)

FAPESP's process: 16/20361-6 - The effect of triclosan on clinical conditions and salivary microbiota in children from generalized aggressive periodontitis parents
Grantee:Henrique Tonelli
Support type: Scholarships in Brazil - Scientific Initiation