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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Selective afferent renal denervation mitigates renal and splanchnic sympathetic nerve overactivity and renal function in chronic kidney disease-induced hypertension

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Veiga, Amanda C. [1] ; Milanez, Maycon I. O. [1] ; Ferreira, Giovanna R. [1] ; Lopes, Nathalia R. [1] ; Santos, Camila P. [1] ; De Angelis, Katia [1] ; Garcia, Michelle L. [1] ; Oyama, Lila M. [1] ; Gomes, Guiomar N. [1] ; Nogueira, Fernando N. [2] ; Carvalho, Polliane M. [2] ; Campos, Ruy R. [1] ; Bergamaschi, Cassia T. [1] ; Nishi, Erika E. [1]
Total Authors: 14
[1] Univ Fed Sao Paulo, Dept Physiol, Escola Paulista Med, Sao Paulo - Brazil
[2] Univ Sao Paulo, Dent Fac, Dept Biomat & Oral Biol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of Hypertension; v. 38, n. 4, p. 765-773, APR 2020.
Web of Science Citations: 0

Background: Clinical and experimental evidence have shown that renal denervation, by removing both the sympathetic and afferent nerves, improves arterial hypertension and renal function in chronic kidney disease (CKD). Given the key role of renal sympathetic innervation in maintaining sodium and water homeostasis, studies have indicated that the total removal of renal nerves leads to impaired compensatory mechanisms during hemodynamic challenges. Method: In the present study, we hypothesized that afferent (or sensory) fibers from the diseased kidney contribute to sympathetic overactivation to the kidney and other target organ, such as the splanchnic region, contributing to hypertension in CKD. We used a method to remove selectively the afferent renal fibers (periaxonal application of 33 mmol/l capsaicin) in a rat model of CKD, the 5/6 nephrectomy. Results: Three weeks after afferent renal denervation (ARD), we found a decrease in mean arterial pressure (similar to 15%) and normalization in renal and splanchnic sympathetic nerve hyperactivity in the CKD group. Interestingly, intrarenal renin--angiotensin system, as well as renal fibrosis and function and proteinuria were improved after ARD in CKD rats. Conclusion: The findings demonstrate that afferent fibers contribute to the maintenance of arterial hypertension and reduced renal function that are likely to be mediated by increased sympathetic nerve activity to the renal territory as well as to other target organs in CKD. (AU)

FAPESP's process: 18/02671-3 - Functional and molecular actions of renal nerve in experimental chronic renal failure
Grantee:Cassia Marta de Toledo Bergamaschi
Support type: Regular Research Grants
FAPESP's process: 13/23741-6 - Evaluation of central mechanisms in the renorenal reflex and the role of afferent renal nerves in renovascular hypertension
Grantee:Erika Emy Nishi
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/03905-5 - Evaluation of renal afferent innervation influence in experimental chronic kidney disease
Grantee:Amanda Costa Veiga
Support type: Scholarships in Brazil - Scientific Initiation