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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A metal-free blue chromophore derived from plant pigments

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Author(s):
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Freitas-Dorr, B. C. [1] ; Machado, C. O. [1] ; Pinheiro, A. C. [1] ; Fernandes, A. B. [1] ; Dorr, F. A. [2] ; Pinto, E. [2] ; Lopes-Ferreira, M. [3] ; Abdellah, M. [4, 5] ; Sa, J. [6, 5] ; Russo, L. C. [7] ; Forti, F. L. [7] ; Goncalves, L. C. P. [1] ; Bastos, L. L. [1]
Total Authors: 13
Affiliation:
[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, BR-05508000 Sao Paulo, SP - Brazil
[3] Butantan Inst, Immunoregulat Unit, Special Lab Appl Toxinol, Ctr Toxins Immune Response & Cell Signaling CEPID, BR-05503900 Sao Paulo, SP - Brazil
[4] South Valley Univ, Qena Fac Sci, Dept Chem, Qena 83523 - Egypt
[5] Uppsala Univ, Dept Chem, Phys Chem Div, Angstrom Lab, S-75120 Uppsala - Sweden
[6] Polish Acad Sci, Inst Phys Chem, PL-01224 Warsaw - Poland
[7] Univ Sao Paulo, Dept Bioquim, Inst Quim, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 7
Document type: Journal article
Source: SCIENCE ADVANCES; v. 6, n. 14 APR 2020.
Web of Science Citations: 0
Abstract

Blue natural pigments are rare, especially among plants. However, flowering species that evolved to attract Hymenoptera pollinators are colored by blue anthocyanin-metal complexes. Plants lacking anthocyanins are pigmented by betalains but are unable to produce blue hues. By extending the pi-system of betalains, we designed a photostable and metal-free blue dye named BeetBlue that did not show toxicity to human hepatic and retinal pigment epithelial cells and does not affect zebrafish embryonal development. This chiral dye can be conveniently synthesized from betalamic acid obtained from hydrolyzed red beetroot juice or by enzymatic oxidation of L-dopa. BeetBlue is blue in the solid form and in solution of acidified polar molecular solvents, including water. Its capacity to dye natural matrices makes BeetBlue the prototype of a new class of low-cost bioinspired chromophores suitable for a myriad of applications requiring a blue hue. (AU)

FAPESP's process: 18/25842-8 - Sources, targets and biological responses of triplet species and singlet oxygen: pathogenicity and quenching
Grantee:Leticia Christina Pires Gonçalves
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/10563-5 - Photophysical properties of betalainic metal complexes
Grantee:Barbara Coelho de Freitas Dörr
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 16/21445-9 - Betalains: structure-property relationships
Grantee:Erick Leite Bastos
Support type: Regular Research Grants
FAPESP's process: 15/25629-4 - Synthesis of fluorescent nanoparticles using betalains
Grantee:Arthur Bonfá Fernandes
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 14/22136-4 - Use of green solvents and their mixtures for optimizing chemical processes
Grantee:Omar Abou El Seoud
Support type: Research Projects - Thematic Grants
FAPESP's process: 19/06391-8 - Photophysical characterization and anti-inflammatory potential of betalains
Grantee:Erick Leite Bastos
Support type: Regular Research Grants
FAPESP's process: 15/24760-0 - Effect of antioxidant plant pigments on the viability of cells subjected to oxidative photoinduced stress
Grantee:Caroline de Oliveira Machado
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 15/18474-4 - Functionalization of polysaccharides with photoresponsive betalains
Grantee:Amanda Capistrano Pinheiro
Support type: Scholarships in Brazil - Doctorate (Direct)