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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Anti-inflammatory and anti-Candida Effects of Brazilian Organic Propolis, a Promising Source of Bioactive Molecules and Functional Food

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Nani, Bruno Dias [1] ; Orlandi Sardi, Janaina de Cassia [1] ; Lazarini, Josy Goldoni [1] ; Silva, Diego Romario [1] ; Massariolli, Adna Prado [2] ; Cunha, Thiago Mattar [3] ; de Alencar, Severino Matias [2] ; Franchin, Marcelo [1] ; Rosalen, Pedro Luiz [1]
Total Authors: 9
[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, BR-13414018 Piracicaba, SP - Brazil
[2] Univ Sao Paulo, Luiz de Queiroz Coll Agr, Dept Agrifood Ind Food & Nutr, BR-13418900 Piracicaba, SP - Brazil
[3] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Agricultural and Food Chemistry; v. 68, n. 10, p. 2861-2871, MAR 11 2020.
Web of Science Citations: 0

Brazilian organic propolis (BOP) is an unexplored Brazilian propolis that is produced organically and certified according to international legislation. Our results showed that BOP has strong anti-inflammatory effects and acts by reducing nuclear factor kappa B activation, tumor necrosis factor a release, and neutrophil migration. In addition, BOP6 exhibited antifungal activity on planktonic and biofilm cultures of Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, and Candida parapsisolis and reduced in vitro yeast cell adhesion to human keratinocytes at sub-inhibitory concentrations. BOP demonstrated significantly low toxicity in Galleria melonella larvae at antifungal doses. Lastly, a chemical analysis revealed the presence of caffeoyltartaric acid, 3,4-dicaffeoylquinic acid, quercetin, and gibberellins A7, A9, and A20, which may be responsible for the biological properties observed. Thus, our data indicate that BOP is a promising source of anti-inflammatory and antifungal molecules that may be used as a functional food. (AU)

FAPESP's process: 17/09898-0 - Bioprospection of novel anti-inflammatory molecules from natural Brazilian native products
Grantee:Pedro Luiz Rosalen
Support type: Regular Research Grants