Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Association between tDCS computational modeling and clinical outcomes in depression: data from the ELECT-TDCS trial

Full text
Show less -
Suen, Paulo J. C. [1] ; Doll, Sarah [2] ; Batistuzzo, Marcelo C. [1] ; Busatto, Geraldo [3, 4] ; Razza, Lais B. [5] ; Padberg, Frank [6] ; Mezger, Eva [6] ; Bulubas, Lucia [6, 7] ; Keeser, Daniel [6, 8] ; Deng, Zhi-De [9, 10] ; Brunoni, Andre R. [5, 11, 12]
Total Authors: 11
Show less -
[1] Univ Sao Paulo, Fac Med FMUSP, Sao Paulo, SP - Brazil
[2] Univ Munster, Dept Psychol, Munster - Germany
[3] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept & Inst Psychiat, Lab Psychiat Neuroimaging, Sao Paulo - Brazil
[5] Univ Sao Paulo, Serv Interdisciplinary Neuromodulat, Inst Nacl Biomarcadores Neuropsiquiatria InBioN, F, Inst Psiquiatria, Lab Neurosci LIM 27, Dept & Inst, R Dr Ovidio Pires Campos 785, 2o Andar, BR-05403000 Ala Sul, SP - Brazil
[6] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich - Germany
[7] IMPRS TP, Munich - Germany
[8] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Clin Radiol, Munich - Germany
[9] NIMH, Noninvas Neuromodulat Unit, Expt Therapeut & Pathophysiol Branch, NIH, Bethesda, MD 20892 - USA
[10] Duke Univ, Sch Med, Dept Psychiat & Behav Sci, Durham, NC - USA
[11] Univ Sao Paulo, Fac Med, Dept Internal Med, Av Prof Lineu Prestes 2565, BR-05508000 Sao Paulo - Brazil
[12] Univ Sao Paulo, Hosp Univ, Av Prof Lineu Prestes 2565, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 12
Document type: Journal article
Web of Science Citations: 3

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation intervention investigated for the treatment of depression. Clinical results have been heterogeneous, partly due to the variability of electric field (EF) strength in the brain owing to interindividual differences in head anatomy. Therefore, we investigated whether EF strength was correlated with behavioral changes in 16 depressed patients using simulated electric fields in real patient data from a controlled clinical trial. We hypothesized that EF strength in the dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC), brain regions implicated in depression pathophysiology, would be associated with changes in depression, mood and anxiety scores. SimNIBS were used to simulate individual electric fields based on the MRI structural T1-weighted brain scans of depressed subjects. Linear regression models showed, at the end of the acute treatment phase, that simulated EF strength was inversely associated with negative affect in the bilateral ACC (left: beta = - 160.463, CI {[}- 291.541, - 29.385], p = 0.021; right: beta = - 189.194, CI {[}- 289.479, - 88.910], p = 0.001) and DLPFC (left: beta = - 93.210, CI {[}- 154.960, - 31.461], p = 0.006; right: beta = - 82.564, CI {[}- 142.867, - 22.262], p = 0.011) and with depression scores in the left ACC (beta = - 156.91, CI {[}- 298.51, - 15.30], p = 0.033). No association between positive affect or anxiety scores, and simulated EF strength in the investigated brain regions was found. To conclude, our findings show preliminary evidence that EF strength simulations might be associated with further behavioral changes in depressed patients, unveiling a potential mechanism of action for tDCS. Further studies should investigate whether individualization of EF strength in key brain regions impact clinical response. (AU)

FAPESP's process: 18/21722-8 - Transcranial direct current stimulation for treatment of depression: an investigation of the dose-response relation by computer modeling of electric fields in the brain
Grantee:Paulo Jeng Chian Suen
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/20911-5 - Escitalopram and transcranial direct current stimulation in major depressive disorder: a double blind, placebo-controlled, randomized, non-inferiority trial
Grantee:Andre Russowsky Brunoni
Support type: Research Grants - Young Investigators Grants