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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Perinatal exposure to bisphenol A impacts in the mammary gland morphology of adult Mongolian gerbils

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Rivas Leonel, Ellen Cristina [1] ; Pegorin Campos, Silvana Gisele [2] ; Baraldi Bedolo, Carolina Marques [1] ; Alves Guerra, Luiz Henrique [1] ; Leite Vilamaior, Patricia Simone [1] ; Calmon, Marilia Freitas [1] ; Rahal, Paula [1] ; Amorim, Christiani Andrade [3] ; Taboga, Sebastiao Roberto [1]
Total Authors: 9
[1] Sao Paulo State Univ UNESP, Inst Biosci Humanities & Exact Sci, Dept Biol, Rua Cristovao Colombo 2265, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[2] Univ Fed Sao Joao del Rei, Campus Ctr Oeste Dona Lindu, BR-35501296 Divinopolis, MG - Brazil
[3] Catholic Univ Louvain, Inst Expt & Clin Res, Lab Gynecol, Ave Mounier 52, Bte B1-52-02, B-1200 Brussels - Belgium
Total Affiliations: 3
Document type: Journal article
Source: Experimental and Molecular Pathology; v. 113, APR 2020.
Web of Science Citations: 0

The endocrine disruptive effects caused by bisphenol A (BPA) are well known. Despite this, to date, evaluation of its long term effects is limited, meaning that there is still much to be unveiled in terms of alterations caused by perinatal exposure to BPA. Our aim was to determine if perinatal exposure to two different doses of BPA causes long term morphological and molecular alteration effects in the mammary gland (MG). We evaluated MG from Mongolian gerbil offspring exposed perinatally (during gestation and lactation) to 50 or 5000 mu g/kg/day BPA. At 90 days of age the animals were subjected to a single dose of N-nitroso-N-methylurea in order to mimic a carcinogenic environment. At 6 months of age, animals in estrous were euthanized for morphological evaluation of the MGs. The MG architecture presented considerable changes in terms of detached epithelial cells, inflammation, glandular hyperplasia, and collagen fiber deposition. Furthermore, a higher index of epithelial cell proliferation was detected in comparison to the intact control group. In addition, we verified a higher molecular expression of EZH2 in the vehicle treated group, indicating that corn oil applied alone can alter the expression of this epigenetic biomarker. In conclusion, BPA perinatal exposure promotes significant changes in glandular cytoarchitecture and increases glandular epithelium proliferation rate, leading to the retention of stem-like properties. This event could compromise the fate and differentiation potential of mammary epithelium. (AU)

FAPESP's process: 15/01548-5 - Evaluation of the Bisphenol-A carcinogenic effect in the mammary gland of Mongolian Gerbil (Merionis unguiculatus)
Grantee:Ellen Cristina Rivas Leonel
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 16/22947-8 - Techniques of female reproductive tissue morphology and viability assessment as tools for enhancing cancer research success
Grantee:Ellen Cristina Rivas Leonel
Support Opportunities: Scholarships abroad - Research Internship - Doctorate