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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Meliponamycins: Antimicrobials from Stingless Bee-Associated Streptomyces sp.

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Menegatti, Carla [1] ; Lourenzon, Vitor Bruno [1] ; Rodriguez-Hernandez, Diego [1] ; da Paixao Melo, Weilan Gomes [1] ; Gomes Ferreira, Leonardo Luiz [2] ; Andricopulo, Adriano Defini [2] ; do Nascimento, Fabio Santos [3] ; Pupo, Monica Tallarico [1]
Total Authors: 8
[1] Univ Sao Paulo, Dept Ciencias Farmaceut, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13563120 Sao Carlos, SP - Brazil
[3] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Biol, BR-14040901 Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Natural Products; v. 83, n. 3, SI, p. 610-616, MAR 27 2020.
Web of Science Citations: 3

Social insects establish complex interactions with microorganisms, some of which play defensive roles in colony protection. The important role of pollinators such as the stingless bee Melipona scutellaris in nature encouraged us to pursue efforts to study its associated microbiota. Here we describe the discovery of two novel cyclic hexadepsipeptides, meliponamycin A (1) and meliponamycin B (2), from Streptomyces sp. ICBG1318 isolated from M. scutellaris nurse bees. Their structures were established by interpretation of NMR and MS data, and the absolute configuration of the constituent amino acids was determined by the advanced Marfey's method. Compounds 1 and 2 showed strong activity against the entomopathogen Paenibacillus larvae and human pathogens Staphylococcus aureus and Leishmania infantum. (AU)

FAPESP's process: 18/07153-0 - Application of OSMAC and co-culture approaches to diversify the secondary metabolism of Streptomyces albiaxialis ICBG1318
Grantee:Vitor Bruno Lourenzon
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 16/15576-3 - Natural products involved in symbiosis between actinobacteria and social insects
Grantee:Carla Menegatti
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/01001-6 - Discovering bacterial symbionts diversity associated with ants in different Brazilian biomes
Grantee:Weilan Gomes da Paixão Melo
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/17620-4 - Bacterial symbionts associated with stingless bee Melipona scutellaris as sources of bioactive natural products
Grantee:Carla Menegatti
Support type: Scholarships in Brazil - Master
FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
Grantee:Glaucius Oliva
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 13/50954-0 - Novel therapeutic agents from the bacterial symbionts of Brazilian invertebrates
Grantee:Mônica Tallarico Pupo
Support type: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 17/01188-4 - Relationship of the protozoan Crithidia spp with bacterioma associated with the stingless bee Melipona scutellaris: chemical, ecological and pharmacological studies
Grantee:Diego Carlos Rodriguez Hernandez
Support type: Scholarships in Brazil - Post-Doctorate