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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hypothalamic IRX3: A New Player in the Development of Obesity

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Author(s):
de Araujo, Thiago Matos [1] ; Velloso, Licio A. [1]
Total Authors: 2
Affiliation:
[1] Univ Estadual Campinas, Obes & Comorbid Res Ctr, Lab Cell Signaling, UNICAMP, Campinas, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: TRENDS IN ENDOCRINOLOGY AND METABOLISM; v. 31, n. 5, p. 368-377, MAY 2020.
Web of Science Citations: 0
Abstract

Genome-wide association studies (GWASs) have identified SNPs of the fat mass and obesity (FTO) gene as the most important risk alleles for obesity. However, how the presence of risk alleles affect phenotype is still a matter of intense investigation. In 2014, a study revealed that long-range enhancers from the intronic regions of the FTO gene regulate iroquois-class homeobox protein (IRX)(3) expression. IRX3 is expressed in hypothalamic pro-opiomelanocortin (POMC) neurons and changes in its expression levels affect body adiposity by modifying food intake and energy expenditure. These findings have placed IRX3 as a potential target for the treatment of obesity. Here, we review studies that evaluated the roles of IRX3 in development, neurogenesis, and body energy homeostasis. (AU)

FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
Grantee:Licio Augusto Velloso
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC