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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Epigenetic changes during ageing and their underlying mechanisms

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Author(s):
Braga, Deisi L. [1, 2] ; Mousovich-Neto, Felippe [1] ; Tonon-da-Silva, Guilherme [1, 2] ; Salgueiro, Willian G. [1, 2] ; Mori, Marcelo A. [1, 3, 4]
Total Authors: 5
Affiliation:
[1] Univ Estadual Campinas, Dept Biochem & Tissue Biol, Rua Monteiro Lobato 255, Campinas 13083862, SP - Brazil
[2] Univ Estadual Campinas, Program Genet & Mol Biol, Campinas 13083862, SP - Brazil
[3] Univ Estadual Campinas, Obes & Comorbid Res Ctr OCRC, Campinas 13083862, SP - Brazil
[4] Univ Estadual Campinas, Expt Med Res Cluster EMRC, Campinas 13083862, SP - Brazil
Total Affiliations: 4
Document type: Review article
Source: BIOGERONTOLOGY; v. 21, n. 4, SI APR 2020.
Web of Science Citations: 1
Abstract

As life expectancy increases worldwide, ageing and age-related diseases arise as a major issue for societies around the globe. Understanding the biological mechanisms underlying the ageing process is thus instrumental for the development of efficient interventions aimed to prevent and treat age-related conditions. Current knowledge in the biogerontology field points to epigenetics as a critical component of the ageing process, not only by serving as a bona-fide marker of biological age but also by controlling and conferring inheritability to cellular and organismal ageing. This is reflected by a myriad of evidences demonstrating the relationship between DNA methylation, histone modifications, chromatin remodeling and small non-coding RNAs and several age-related phenotypes. Given the reversibility of epigenetic alterations, epigenetic reprogramming may also be envisioned as a potential approach to treat age-related disorders. Here we review how different types of epigenetic mechanisms are involved in the ageing process. In addition, we highlight how interventions modulate epigenetics and thus promote health- and lifespan. (AU)

FAPESP's process: 17/22057-5 - Physiological effects and transgenerational inheritance induced by cholesterol-rich diet in Caenorhabditis elegans
Grantee:Willian Goulart Salgueiro
Support type: Scholarships in Brazil - Master
FAPESP's process: 17/08829-5 - Investigation of the interaction between Dicer and the NAD+ signalling pathway in C. elegans metabolism and aging
Grantee:Guilherme Tonon da Silva
Support type: Scholarships in Brazil - Master
FAPESP's process: 17/01184-9 - CAMeLEOm: cross-species analysis of metabolic, lifespan effects and omics of dietary restriction mimetics
Grantee:Marcelo Alves da Silva Mori
Support type: Research Projects - Thematic Grants
FAPESP's process: 18/11672-3 - Characterization in mice of novel genes involved in the evolutionarily conserved mechanisms of dietary restriction and its mimetics
Grantee:Felippe Mousovich Neto
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 18/11792-9 - Characterization in C. elegans of novel genes involved in aging and the evolutionarily conserved mechanisms of dietary restriction mimetics
Grantee:Deisi Lilian Braga
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 19/14391-8 - Screening and characterization of Dicer regulators in c. elegans
Grantee:Willian Goulart Salgueiro
Support type: Scholarships abroad - Research Internship - Master's degree