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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antifungal activity of 2 `-hydroxychalcone loaded in nanoemulsion against Paracoccidioides spp.

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Author(s):
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Medina-Alarcon, Kaila P. [1] ; Singulani, Junya de L. [1] ; Dutra, Luiz A. [2] ; Pitangui, Nayla de S. [1] ; Pereira-da-Silva, Marcelo A. [3, 4] ; dos Santos, Mariana B. [5] ; Ayusso, Gabriela M. [5] ; Regasini, Luis O. [5] ; Soares, Christiane P. [6] ; Chorilli, Marlus [7] ; Mendes-Giannini, Maria Js [1] ; Fusco-Almeida, Ana M. [1]
Total Authors: 12
Affiliation:
[1] Univ Estadual Paulista UNESP, Fac Ciencias Farmaceut, Prote Ctr, Mycol Lab, Araraquara, SP - Brazil
[2] Res Inst UNICAMP, Struct Genom Consortium, Campinas, SP - Brazil
[3] IFSC USP, Inst Phys Sao Carlos, Sao Carlos, SP - Brazil
[4] UNICEP, Paulista Central Univ Ctr, Sao Carlos, SP - Brazil
[5] Univ Estadual Paulista UNESP, Inst Biociencias Letras & Ciencias Exatas, Dept Chem & Environm Sci, Sao Jose Do Rio Preto, SP - Brazil
[6] Univ Estadual Paulista UNESP, Fac Ciencias Farmaceut, Dept Clin Anal, Cytol Lab, Araraquara, SP - Brazil
[7] Univ Estadual Paulista UNESP, Fac Ciencias Farmaceut, Dept Drugs & Med, Araraquara, SP - Brazil
Total Affiliations: 7
Document type: Journal article
Source: FUTURE MICROBIOLOGY; v. 15, n. 1, p. 21-33, JAN 2020.
Web of Science Citations: 0
Abstract

Aim: This study aimed to evaluate the activity of 2-hydroxychalcone-loaded in nanoemulsion (NLS + 2 ` chalc), the cytotoxic effect and toxicity against Paracoccidioides brasiliensis and Paracoccidioides lutzii using a zebrafish model. Materials \& methods: Preparation and physical-chemical characterization of nanoemulsion (NLS) and NLS + 2 ` chalc were performed. MIC and minimum fungicide concentration, cytotoxicity and toxicity were also evaluated in the Danio rerio model. Results: NLS + 2 ` chalc showed fungicidal activity against Paracoccidioides spp. without cytotoxicity in MRC5 and HepG2 lines. It also had high selectivity index values and no toxicity in the zebrafish model based on MIC values. Conclusion: NLS + 2 ` chalc is a potential new alternative treatment for paracoccidioidomycosis. Graphical abstract (AU)

FAPESP's process: 16/05581-0 - Development of an antifungal prototype nanostructured lipid against Paracoccidioides brasiliensis and Paracoccidioides lutzii biofilms and assessment of toxicity in zebrafish animal model
Grantee:Giovana Garcia Ferin
Support type: Scholarships in Brazil - Scientific Initiation