| Full text | |
| Author(s): Show less - |
Pott-Junior, Henrique
[1]
;
Crispim Nascimento, Carla Manuela
[2]
;
Costa-Guarisco, Leticia Pimenta
[2]
;
de Oliveira Gomes, Grace Angelica
[2]
;
Gramani-Say, Karina
[2]
;
Orlandi, Fabiana de Souza
[2]
;
Martins Gratao, Aline Cristina
[2]
;
dos Santos Orlandi, Ariene Angelini
[3]
;
Iost Pavarini, Sofia Cristina
[2]
;
Vasilceac, Fernando Augusto
[2]
;
Zazzetta, Marisa Silvana
[2]
;
Cominetti, Marcia Regina
[2]
Total Authors: 12
|
| Affiliation: | [1] Fed Univ Sao Carlos UFSCar, Dept Med, BR-13565905 Sao Carlos - Brazil
[2] Fed Univ Sao Carlos UFSCar, Dept Gerontol, BR-13565905 Sao Carlos - Brazil
[3] Fed Univ Sao Carlos UFSCar, Dept Nursing, BR-13565905 Sao Carlos - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | NUTRIENTS; v. 12, n. 3 MAR 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
This study investigated the relationship between metabolic parameters and low serum 25-hydroxyvitamin D (25(OH)D) levels in older adults (n = 265). They were assessed for anthropometrics and metabolic measurements, including 25(OH)D, insulin, glucose, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and other inflammatory markers. Vitamin D deficiency was defined as a 25(OH)D level below 50 nmol/L. Comparisons between groups were performed using Wilcoxon-Mann-Whitney or Pearson's Chi-squared test. A multivariate adjusted Poisson regression was used to model the number of metabolic parameters as a function of a set of explanatory variables. Subjects with 25(OH)D deficiency were predominantly females and presented higher body weight, body mass index, waist circumference, triglycerides and Tumor Necrosis Factor-alpha (TNF-alpha), and higher insulin resistance. Metabolic syndrome was also more prevalent among 25(OH)D-deficient subjects. In those without metabolic syndrome, 25(OH)D deficiency was related only to obesity and higher insulin resistance. Female sex, hypertension, higher waist circumference and higher levels of hemoglobin A1C (%), HDL-C, and TG were significantly associated with an increased number of metabolic syndrome parameters after adjusting for covariates, but 25(OH)D was not. The fact that serum 25(OH)D concentration was inversely associated with metabolic syndrome and insulin resistance not only reaffirms the relevance to consider serum 25(OH)D concentration as an influencing factor for insulin resistance, but also the need to actively screen for hypovitaminosis D in all patients with this condition. (AU) | |
| FAPESP's process: | 16/15235-1 - Frailty monitoring software for the elderly assisted in health primary care: evaluation of its effectiveness and efficiency |
| Grantee: | Marisa Silvana Zazzetta |
| Support Opportunities: | Research Grants - Research in Public Policies for the National Health Care System (PP-SUS) |
| FAPESP's process: | 14/50104-0 - Fragility monitoring software for the elderly assisted by the Family Health Support Center (NASF) at São Carlos - SP - Brazil |
| Grantee: | Marisa Silvana Zazzetta |
| Support Opportunities: | Research Grants - Research in Public Policies for the National Health Care System (PP-SUS) |