Periodontal disease: Repercussions in pregnant woman and newborn health-A cohort study

Author(s)

Otsuka Padovan Figueiredo, Marina Guim ^[1] ; Takita, Stefanie Yaemi ^[1] ; Ramos Douradol, Bianca Maria ^[1] ; Mendes, Helderjan de Souza ^[2] ; Terakado, Erick Olsen ^[3] ; de Carvalho Nunes, Helio Rubens ^[1] ; Branco da Fonseca, Catia Regina ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Botucatu Med Sch, Pediat Dept, Botucatu, SP - Brazil

^[2] Botucatu Clin Hosp, Botucatu, SP - Brazil

^[3] Paulista Univ Nip, Psychol Dept, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: PLoS One; v. 14, n. 11 NOV 22 2019.
• Web of Science Citations: 0

Abstract

The periodontal disease during pregnancy triggers an exacerbated immune response with high local and systemic concentrations of inflammatory markers. Objective To investigate the repercussion of periodontal disease (PD) in the pregnant woman health and the complications during pregnancy and delivery, as well as negative outcomes for the newborn (as infections, prematurity, low birth weight and fetal growth restriction). Method Retrospective cohort study, based on medical records of 142 pregnant women assisted at a prenatal service of usual risk between 2012-2014, with a dental evaluation for PD. Maternal variables, along with labor and newborn variables, were analyzed. The newborns were stratified into two groups: offspring of mothers with PD (subdivided into Severe Periodontal Disease-SPD) and offspring of mothers without PD. Each outcome was adjusted by a multiple logistic regression model, with significance for p-value < 0.05, considering all potential confounding factors. Results Among women diagnosed with SPD, the odds ratio for vulvovaginitis was 3.45 times greater (OR = 3.45, p-value = 0.050) and 5.59 times higher for premature rupture of membranes (OR = 5.59; p-value = 0.017). For neonates, the chance of fetal growth restriction was 11.53 times higher for pregnant women with SPD (OR = 11.53, p = 0.041). Conclusion The periodontal disease increased the chance of neonatal and maternal negative outcomes, being the fetal growth restriction, vulvovaginitis and premature rupture of the membrane (PROM) the main results driven by the presence of Severe Periodontal Disease. (AU)

• FAPESP's process: 15/23313-0 - Periodontal disease in pregnant women: pregnancy and childbirth consequences
• Grantee: Stefanie Yaemi Takita
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 13/12053-1 - Conditions of oral health of pregnancy from Botucatu (São Paulo State) and its knowledge about the importance of oral health in pregnancy
• Grantee: Jose Carlos Peraçoli
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/23304-0 - Periodontal disease in pregnant women and its consequences for the newborn
• Grantee: Marina Guim Otsuka Padovan Figueiredo
• Support Opportunities: Scholarships in Brazil - Scientific Initiation