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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

``I put it in my head that the supplement would help me{''}: Open-placebo improves exercise performance in female cyclists

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Saunders, Bryan [1, 2] ; Saito, Tiemi [2] ; Klosterhoff, Rafael [3, 2] ; de Oliveira, Luana Farias [2] ; Barreto, Gabriel [2] ; Perim, Pedro [2] ; Pinto, Ana Jessica [2] ; Lima, Fernanda [2, 4] ; de Sapinto, Ana Lucia [2, 4] ; Gualano, Bruno [2, 4]
Total Authors: 10
[1] Univ Sao Paulo, Inst Orthopaed & Traumatol, Fac Med FMUSP, Sao Paulo - Brazil
[2] Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Sch Phys Educ & Sport, Rheumatol Div, Fac Med FMUSP, Sao Paulo - Brazil
[3] Univ Fed Parana, Dept Biochem & Mol Biol, Curitiba, Parana - Brazil
[4] Univ Sao Paulo, Div Rheumatol, Lab Assessment & Conditioning Rheumatol LACRE, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: PLoS One; v. 14, n. 9 SEP 24 2019.
Web of Science Citations: 2

This study investigated the effect of open-placebo on cycling time-trial (TT) performance. Twenty-eight trained female cyclists completed a 1-km cycling TT following a control session or an open-placebo intervention. The intervention consisted of an individual presentation, provided by a medic, in which the concept of open-placebo was explained to the participant, before she ingested two red and white capsules containing flour; 15 min later, they performed the TT. In the control session, the participant sat quietly for 20 min. Heart rate and ratings of perceived exertion (RPE) were monitored throughout exercise, while blood lactate was determined pre- and post-exercise. Post-exercise questionnaires were employed to gain insight into the perceived influence of the supplement on performance. Open-placebo improved time-to-completion (P = 0.039, 103.6 +/- 5.0 vs. 104.4 +/- 5.1 s, -0.7 +/- 1.8 s, -0.7 +/- 1.7%) and mean power output (P = 0.01, 244.8 +/- 34.7 vs. 239.7 +/- 33.2, +5.1 +/- 9.5 W) during the TT. Individual data analysis showed that 11 individuals improved, 13 remained unchanged and 4 worsened their performance with open-placebo. Heart rate, RPE and blood lactate were not different between sessions (all P>0.05). Positive expectation did not appear necessary to induce performance improvements, suggesting unconscious processes occurred, although a lack of an improvement appeared to be associated with a lack of belief. Open-placebo improved 1-km cycling TT performance in trained female cyclists. Although the intervention was successful for some individuals, individual variation was high, and some athletes did not respond or even performed worse. Thus, open-placebo interventions should be carefully considered by coaches and practitioners, while further studies are warranted. (AU)

FAPESP's process: 15/26937-4 - Studies on physical (in)activity in patients with rheumatoid arthritis: characterization, associations with disease and effects of breaking up sedentary time
Grantee:Ana Jéssica Pinto
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 16/50438-0 - Nutritional suplementation and exercise to optimize exercise performance: focus on individual responses and a step towards personalized sports nutrition
Grantee:Bryan Saunders
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 18/01594-5 - Blood and muscle responses to sodium bicarbonate supplementation and subsequent exercise performance
Grantee:Pedro Henrique Lopes Perim
Support type: Scholarships in Brazil - Master
FAPESP's process: 17/15314-1 - The influence of the CYP1A2 polymorphism on the physiological responses and performance following acute supplementation with caffeine
Grantee:Gabriel Henrique Castanho Barreto
Support type: Scholarships in Brazil - Master
FAPESP's process: 17/04973-4 - Nutritional supplementation and exercise to optimise exercise performance: focus on individual responses and a step towards personalized sports nutrition
Grantee:Bryan Saunders
Support type: Scholarships in Brazil - Young Researchers