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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nitric Oxide Releasing Polyamide Dendrimer with Anti-inflammatory Activity

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Garzon-Porras, Ana M. [1, 2] ; Bertuzzi, Diego L. [1] ; Lucas, Kurt [2] ; da Silva, Laura C. E. [1] ; de Oliveira, Marcelo G. [1] ; Ornelas, Catia [1]
Total Authors: 6
[1] Univ Campinas Unicamp, Inst Chem, BR-13083861 Campinas, SP - Brazil
[2] Max Planck Inst Chem, D-55128 Mainz - Germany
Total Affiliations: 2
Document type: Journal article
Source: ACS APPLIED POLYMER MATERIALS; v. 2, n. 5, p. 2027-2034, MAY 2020.
Web of Science Citations: 0

Inflammatory processes are related to a wide variety of diseases with high global impact. Nitric oxide (NO) is an excellent candidate for the treatment of such diseases due to its important anti-inflammatory role in living systems, which is related to its concentration in the cellular medium that in turn depends directly on its release rate from NO releasing compounds. In this work, we synthesized a nitrate-terminated dendrimer and evaluated its anti-inflammatory properties. Remarkably, dendrimer bearing 18 NO-releasing groups was nontoxic, and exhibited anti-inflammatory activity (13.7-27.9% of IL-8 inhibition) throughout the tested concentrations (6.50 X 10(-2) to 4.17 X 10(3) nM of dendrimer; (1.17-7 SO x 10(4) nM of NO-moiety) On the other hand, the NO-releasing monomer was pro-inflammatory at concentrations higher than 62.5 nM. Investigation of the NO-releasing profiles from monomer and dendrimer using real-time NO analyzer NOA confirmed the slow release of NO from the dendrimer. Our results suggest that the NO release from the dendrimer occurs in a controlled fashion, keeping the anti-inflammatory effect of NO even at high concentrations. (AU)

FAPESP's process: 18/14142-5 - Hybrid hydrogels for local and prolonged nitric oxide release
Grantee:Laura Caetano Escobar da Silva
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 18/02093-0 - Development of new nanomaterials for nanomedicine applications
Grantee:Cátia Cristina Capêlo Ornelas Megiatto
Support type: Regular Research Grants
FAPESP's process: 15/23761-2 - Development of new well-defined multifunctional dendrimers for applications in nanomedicine
Grantee:Cátia Cristina Capêlo Ornelas Megiatto
Support type: Regular Research Grants
FAPESP's process: 15/04929-0 - Development of biosensors for instantaneous detection of proteins and cancer cells, for application on on-site biopsy
Grantee:Diego Luan Bertuzzi
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 16/02414-5 - Topical and absorbable biomaterials for the local nitric oxide release
Grantee:Marcelo Ganzarolli de Oliveira
Support type: Research Projects - Thematic Grants