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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Moderate intake of BCAA-rich protein improves glucose homeostasis in high-fat-fed mice

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Roquetto, Aline Rissetti [1] ; Moura, Carolina Soares [1] ; Santos-Junior, Valfredo de Almeida [1] ; Sammarco Oliveira, Paulo Otavio [1] ; Aires Machado, Karla Idelca [1] ; Borges Castro Carvalho, Gessika Cristina [1] ; Risso, Eder Muller [1] ; Amaya-Farfan, Jaime [1]
Total Authors: 8
[1] Univ Campinas UNICAMP, Food & Nutr Program, Sch Food Engn, Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Web of Science Citations: 0

Notwithstanding the fact that dietary branched-chain amino acids (BCAAs) have been considered to be a cause of insulin resistance (IR), evidence indicates that BCAA-rich whey proteins (WPs) do not lead to IR in animals consuming high-fat (HF) diets and may instead improve glucose homeostasis. To address the role of BCAA-rich WP as dietary protein in IR and inflammatory response, we fed C57BLJ6J mice either high-fat (HF) or low-fat (LF) diets formulated with moderate protein levels (13% w/w) of either WP or hydrolyzed WP (WPH) and compared them with casein (CAS) as a reference. The muscle and plasma free amino acid profiles, inflammatory parameters and glycemic homeostasis were examined. While the LF/CAS diet promoted the rise in triglycerides and inflammatory parameters, the HF/CAS induced typical IR responses and impaired biochemical parameters. No differences in plasma BCAAs were detected, but the HF/WPH diet led to a twofold increase in gastrocnemius muscle free amino acids, including BCAAs. In general, ingestion of WPH was effective at averting or attenuating the damage caused by both the LF and HFdiets. No high concentrations of BCAAs in the plasma or signs of IR were found in those mice fed an HF diet along with the hydrolyzed whey proteins. It is concluded that consumption of BCAA-rich whey proteins, especially WPH, does not result in the development of IR. (C) 2020 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 17/16886-9 - Effect of whey protein intake on heat shock proteins (HSPs) and intestinal microbiot in obese rats induced by cafeteria diet
Grantee:Jaime Amaya Farfan
Support Opportunities: Regular Research Grants
FAPESP's process: 16/06630-4 - Effect of whey protein intake on heat shock proteins (HSPs) in obese rats induced by cafeteria diet
Grantee:Carolina Soares de Moura
Support Opportunities: Scholarships in Brazil - Post-Doctorate