| Full text | |
| Author(s): |
Lima, Flavia Afonso
[1]
;
Barateiro, Andre
[1]
;
Dombrowski, Jamille Gregorio
[1]
;
de Souza, Rodrigo Medeiros
[2]
;
Costa, Douglas de Sousa
[1]
;
Murillo, Oscar
[1]
;
Epiphanio, Sabrina
[3]
;
Goncalves, Ligia Antunes
[1]
;
Farias Marinho, Claudio Romero
[1]
Total Authors: 9
|
| Affiliation: | [1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Sao Paulo - Brazil
[2] Univ Fed Acre, Multidisciplinary Ctr, Acre - Brazil
[3] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | PLoS One; v. 14, n. 12 DEC 5 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Plasmodium (P.) falciparum malaria during pregnancy has been frequently associated with severe consequences such as maternal anemia, abortion, premature birth, and reduced birth weight. Placental damage promotes disruption of the local homeostasis; though, the mechanisms underlying these events are still to be elucidated. Autophagy is a fundamental homeostatic mechanism in the natural course of pregnancy by which cells self-recycle in order to survive in stressful environments. Placentas from non-infected and P. falciparum-infected women during pregnancy were selected from a previous prospective cohort study conducted in the Brazilian Amazon (Acre, Brazil). Newborns from infected women experienced reduced birth weight (P = 0.0098) and placental immunopathology markers such as monocyte infiltrate (P < 0.0001) and IL-10 production (P = 0.0122). The placentas were evaluated for autophagy-related molecules. As a result, we observed reduced mRNA levels of ULK1 (P = 0.0255), BECN1 (P = 0.0019), and MAP1LC3B (P = 0.0086) genes in placentas from P. falciparum-infected, which was more striking in those diagnosed with placental malaria. Despite the protein levels of these genes followed the same pattern, the observed reduction was not statistically significant in placentas from P. falciparum-infected women. Nevertheless, our data suggest that chronic placental immunopathology due to P. falciparum infection leads to autophagy dysregulation, which might impair local homeostasis during malaria in pregnancy that may result in poor pregnancy outcomes. (AU) | |
| FAPESP's process: | 17/03939-7 - Impact of autophagy and inflammasome on the pathogenesis of Placental Malaria |
| Grantee: | André Filipe Rivais Martins Barateiro |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 17/05782-8 - The study of vascular permeability in the malaria-associated acute respiratory distress syndrome |
| Grantee: | Sabrina Epiphanio |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/16417-8 - Autophagy in placental malaria: effects and mechanisms |
| Grantee: | Flávia Afonso Lima |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 12/04755-3 - Association of gestational malaria with intrauterine growth restriction and low birth weight in the far-western Brazilian Amazon |
| Grantee: | Jamille Gregório Dombrowski |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 16/07030-0 - Characterization of autophagic activity and inflammasome in placental malaria |
| Grantee: | Cláudio Romero Farias Marinho |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/06106-0 - The role of inflammasomes in the pathogenesis of malaria during pregnancy: effects and mechanisms |
| Grantee: | Cláudio Romero Farias Marinho |
| Support Opportunities: | Research Grants - Visiting Researcher Grant - International |
| FAPESP's process: | 13/00981-1 - Characterization of the role of dendritic cells in the recrudescence of malaria in pregnancy |
| Grantee: | Oscar Javier Murillo Gómez |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 18/20468-0 - Recrudescence of the malaria during pregnancy: effects and mechanisms |
| Grantee: | Cláudio Romero Farias Marinho |
| Support Opportunities: | Regular Research Grants |