Global Distribution and Evolution of Mycobacterium bovis Lineages

Author(s):Show less -

Zimpel, Cristina Kraemer ^{[1, 2]} ; Patane, Jose Salvatore L. ^{[3, 4]} ; Proenga Guedes, Aureliano Coelho ^[5] ; de Souza, Robson F. ^[5] ; Silva-Pereira, Taiana T. ^{[1, 2]} ; Soler Camargo, Naila C. ^{[1, 2]} ; de Souza Filho, Antonio F. ^[1] ; Ikuta, Cassia Y. ^[1] ; Ferreira Neto, Jose Soares ^[1] ; Setubal, Joao Carlos ^{[3, 6]} ; Heinemann, Marcos Bryan ^[1] ; Sa Guimaraes, Ana Marcia ^[2]

Affiliation

^[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Prevent Vet Med & Anim Hlth, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Lab Appl Res Mycobacteria, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Inst Chem, Dept Biochem, Sao Paulo - Brazil

^[4] Butantan Inst, Lab Cellular Cycle, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Inst Biomed Sci, Lab Prot Struct & Evolut, Dept Microbiol, Sao Paulo - Brazil

^[6] Virginia Tech, Biocomplex Inst, Blacksburg, VA - USA

• Document type: Journal article
• Source: FRONTIERS IN MICROBIOLOGY; v. 11, MAY 7 2020.
• Web of Science Citations: 1

Abstract

Mycobacterium bovis is the main causative agent of zoonotic tuberculosis in humans and frequently devastates livestock and wildlife worldwide. Previous studies suggested the existence of genetic groups of M. bovis strains based on limited DNA markers (a.k.a. clonal complexes), and the evolution and ecology of this pathogen has been only marginally explored at the global level. We have screened over 2,600 publicly available M. bovis genomes and newly sequenced four wildlife M. bovis strains, gathering 1,969 genomes from 23 countries and at least 24 host species, including humans, to complete a phylogenomic analyses. We propose the existence of four distinct global lineages of M. bovis (Lb1, Lb2, Lb3, and Lb4) underlying the current disease distribution. These lineages are not fully represented by clonal complexes and are dispersed based on geographic location rather than host species. Our data divergence analysis agreed with previous studies reporting independent archeological data of ancient M. bovis (South Siberian infected skeletons at similar to 2,000 years before present) and indicates that extant M. bovis originated between 715 and 3,556 years BP, with later emergence in the New World and Oceania, likely influenced by trades among countries. (AU)

• FAPESP's process: 17/04617-3 - Host adaption of Mycobacterium tuberculosis and Mycobacterium bovis: a genomic and transcriptional approach
• Grantee: Cristina Kraemer Zimpel
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/20147-7 - Investigation of the pseudogenization rate among genomes of the Mycobacterium tuberculosis complex
• Grantee: Naila Cristina Soler Camargo
• Support Opportunities: Scholarships in Brazil - Scientific Initiation