Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chick embryo chorioallantoic membrane as a suitable in vivo model to evaluate drug delivery systems for cancer treatment: A review

Full text
Author(s):
Victorelli, Francesca Damiani [1] ; de Oliveira Cardoso, Valeria Maria [1] ; Ferreira, Natalia Noronha [1] ; Fioramonti Calixto, Giovana Maria [1, 2] ; Fontana, Carla Raquel [3] ; Baltazar, Fatima [4, 5] ; Daflon Gremiao, Maria Palmira [1] ; Chorilli, Marlus [1]
Total Authors: 8
Affiliation:
[1] Sao Paulo State Univ, Sch Pharmaceut Sci, Dept Drugs & Med, UNESP, BR-14800903 Araraquara, SP - Brazil
[2] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Biosci, UNICAMP, BR-13414903 Piracicaba, SP - Brazil
[3] Sao Paulo State Univ, Sch Pharmaceut Sci, Dept Clin Anal, UNESP, BR-14800903 Araraquara, SP - Brazil
[4] ICVS 3Bs PT Govt Associate Lab, P-4710057 Braga - Portugal
[5] Univ Minho, Sch Med, Life & Hlth Sci Res Inst ICVS, P-4710057 Braga - Portugal
Total Affiliations: 5
Document type: Review article
Source: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS; v. 153, p. 273-284, AUG 2020.
Web of Science Citations: 0
Abstract

Cancer represents a significant public health problem. More than 18.1 million people are annually diagnosed with cancer and 9.6 million die mainly due to metastatic disease. Chemotherapy has been one of the main cancer treatment modalities; however, most of the chemotherapeutic agents are non-specific, exhibiting several toxic side effects, which compromises the patient's quality of life. Therefore, it is necessary to search for new therapeutic alternatives, using for example, drug delivery systems (DDS) to target cancer cells, increasing the selectivity of chemotherapeutic drugs. This approach is promising; however, it is crucial to evaluate the biological performance of the systems. Although mammalian models continue to be explored for clinical applications, they are time-consuming and very restrictive from the ethical and legal perspectives. Hence, the chick embryo chorioallantoic membrane (CAM) has been shown to be a suitable in vivo model since it allows a more appropriate model for the study of drugs and/or DDS performance than in vitro tests. Thereby, this article revises the recent advances of DDS for cancer therapy, evaluating the feasibility of the CAM model. (AU)

FAPESP's process: 14/50928-2 - INCT 2014: Pharmaceutical Nanotechnology: a transdisciplinary approach
Grantee:Maria Vitória Lopes Badra Bentley
Support type: Research Projects - Thematic Grants
FAPESP's process: 19/07245-5 - Lidocaine and epinephrine co-loaded mucoadhesive liquid crystal precursor systems as a strategy for topical anesthesia in the buccal cavity
Grantee:Giovana Maria Fioramonti Calixto Balian
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 18/04546-1 - EVALUATION OF SYNERGIC EFFECT BETWEEN CHC AND CETUXIMAB AGAINST GLIOBLASTOMA USING DRUG DELIVERY SYSTEMS
Grantee:Natália Noronha Ferreira Naddeo
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 13/01565-1 - Mucoadhesive precursor systems of liquids crystals for buccal admnistration of antigelatinolytic peptide associated with photodynamic therapy in the treatment of oral cancer
Grantee:Giovana Maria Fioramonti Calixto Balian
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/09671-3 - Nanostructured multifunctional systems for drug controlled release through nasal route on glioblastomas treatment
Grantee:Natália Noronha Ferreira Naddeo
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/21412-0 - Gellan/retrograded starch mucoadhesives systems intended for the colonic release of bevacizumab to cancer treatment.
Grantee:Valéria Maria de Oliveira Cardoso
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/06337-5 - Evaluation of the effects of CTT1-loaded liquid crystalline system associated to photodynamic therapy in tumor growth using chorioallantoic membrane
Grantee:Giovana Maria Fioramonti Calixto Balian
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 17/10016-2 - Liquid crystal precursor systems as a strategy for vaginal administration of CTT1 peptide: pharmacotechnical development and potential application for the treatment of cervical cancer
Grantee:Marlus Chorilli
Support type: Regular Research Grants
FAPESP's process: 17/23357-2 - Potential evaluation of liquid crystal precursors systems for vaginal administration of curcumin in the cervical cancer treatment
Grantee:Francesca Damiani Victorelli
Support type: Scholarships in Brazil - Master