Cardiac structural and functional findings in Persian cats with autosomal dominant polycystic kidney disease

Author(s):Show less -

Juliana Mariotti Guerra ; Arine Pellegrino ^[2] ; Alexandre Gonçalves Teixeira Daniel ^[3] ; Mariana Ferreira de Freitas ^[4] ; Natália Cavalca Cardoso ^[5] ; Rebecca Bastos Pessoa ^[6] ; Gabriel Garone de Lucca ^[7] ; Maria Helena Matiko Akao Larsson ^[8] ; Luiz Fernando Onuchic ^[9] ; Felisbina Luisa Queiroga ^[10] ; Bruno Cogliati ^[11]

• Document type: Journal article
• Source: Ciência Rural; v. 50, n. 9 2020-08-07.

Abstract

ABSTRACT: Autosomal dominant polycystic kidney disease (ADPKD) has been related to left ventricular structural and functional abnormalities in human patients. The present study aimed to evaluate the cardiac structural and functional findings in Persian cats with ADPKD. Client-owned ADPKD (n=12) and non-ADPKD (n=12) Persian cats were enrolled in this study. The animals underwent echo- and electrocardiographic (ECG) examinations, and non-invasive measurements of systolic blood pressure (SBP) were obtained. Both groups were similar regarding hematological and biochemical parameters, including white blood cell count and levels of blood urea nitrogen, creatinine, total protein and thyroxine. There were no differences related to ECG parameters between ADPKD and non-ADPKD cats. Left ventricular hypertrophy (LVH) was demonstrated in 6/12 (50%) normotensive ADPKD cats with preserved renal function. There were no differences between animal groups regarding the echocardiographic parameters, including left ventricular ejection fraction and shortening fraction; however, basal interventricular septal thickness at end-diastole near the left ventricular outflow tract and aortic artery flow velocity showed slightly elevated values in ADPKD-cats. Our study revealed that Persian cats with ADPKD do not reproduce the functional and structural cardiac phenotype reported in human patients; however, large-scale cohort studies are necessary to distinguish the possibilities of a true linkage between ventricular myocardial hypertrophy and ADPKD in this breed. (AU)

• FAPESP's process: 13/06471-5 - Comparative study of DNA extraction in different biological material sources to performance the polymerase chain reaction (PCR) in the diagnosis of Polycystic Kidney Disease in Persian cats
• Grantee: Natalia Cavalca Cardoso
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 12/04990-2 - Hypertrophic cardiomyopathy in Persian cats: mutational analysis of genes encoding sarcomeric proteins and correlation with cardiac symptoms
• Grantee: Maria Helena Matiko Akao Larsson
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/19614-6 - Autosomal dominant polycystic kidney disease in Persian cats: genotypic and phenotypic characterization and elaboration of criteria for ultrasonographic diagnosis
• Grantee: Luiz Fernando Onuchic
• Support Opportunities: Regular Research Grants