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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antigen 5 Allergens of Hymenoptera Venoms and Their Role in Diagnosis and Therapy of Venom Allergy

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Blank, Simon [1, 2, 3] ; Bazon, Murilo Luiz [1, 2, 3, 4] ; Grosch, Johannes [1, 2, 3] ; Schmidt-Weber, Carsten B. [1, 2, 3] ; Brochetto-Braga, Marcia Regina [4] ; Bilo, Maria Beatrice [5] ; Jakob, Thilo [6]
Total Authors: 7
[1] Tech Univ Munich, German Res Ctr Environm Hlth, Sch Med, Ctr Allergy & Environm ZAUM, Ingolstadter Landstr 1, D-85764 Munich - Germany
[2] Tech Univ Munich, German Res Ctr Environm Hlth, Helmholtz Ctr Munich, Ingolstadter Landstr 1, D-85764 Munich - Germany
[3] Tech Univ Munich, German Ctr Lung Res DZL, Ingolstadter Landstr 1, D-85764 Munich - Germany
[4] Sao Paulo State Univ, Biosci Inst, Dept Gen & Appl Biol, Rio Claro, SP - Brazil
[5] Polytech Univ Marche, Univ Hosp Ancona, Dept Internal Med, Dept Clin & Mol Sci, Ancona & Allergy Unit, Ancona - Italy
[6] Justus Liebig Univ Giessen, Dept Dermatol & Allergol, Expt Dermatol & Allergy Res Grp, Giessen - Germany
Total Affiliations: 6
Document type: Review article
Source: CURRENT ALLERGY AND ASTHMA REPORTS; v. 20, n. 10 JUL 9 2020.
Web of Science Citations: 0

Purpose of ReviewStings of Hymenoptera of the superfamily Vespoidea such as yellow jackets, paper wasps or stinging ants are common triggers for severe and even fatal allergic reactions. Antigen 5 allergens are potent allergens in the majority of these venoms with major importance for diagnosis and therapy. Reviewed here are the characteristics of antigen 5 allergens, their role in component-resolved diagnostics as well as current limitations of the available diagnostics for proper therapeutic decisions.Recent FindingsAntigens 5 are proteins of unknown function in Hymenoptera venoms with high allergenic potency. They represent key elements in component-resolved diagnosis to discriminate between honeybee and vespid venom allergy. However, due to their pronounced cross-reactivity, there are remaining diagnostic and therapeutic challenges that have to be addressed.SummaryAntigens 5 are highly relevant venom allergens of the Vespoidea superfamily. Although their use in component-resolved diagnosis facilitates dissection of cross-reactivity and primary allergy in double sensitization to honeybee and vespid venom, new diagnostic concepts are needed to discriminate between allergies to different vespid species. (AU)

FAPESP's process: 19/02298-3 - Characterization of the immunological potential of the recombinant antigen 5 from Polybia paulista venom
Grantee:Murilo Luiz Bazon
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 17/07988-2 - Biological and inflammatory evaluation of the antigen 5 from the venom of Polybia paulista (Hymenoptera, Vespidae) in the recombinant form, on cells of macrophagic lineage
Grantee:Murilo Luiz Bazon
Support Opportunities: Scholarships in Brazil - Doctorate