Antigen 5 Allergens of Hymenoptera Venoms and Their Role in Diagnosis and Therapy of Venom Allergy

Author(s)

Blank, Simon ^{[1, 2, 3]} ; Bazon, Murilo Luiz ^{[1, 2, 3, 4]} ; Grosch, Johannes ^{[1, 2, 3]} ; Schmidt-Weber, Carsten B. ^{[1, 2, 3]} ; Brochetto-Braga, Marcia Regina ^[4] ; Bilo, Maria Beatrice ^[5] ; Jakob, Thilo ^[6]

Affiliation

^[1] Tech Univ Munich, German Res Ctr Environm Hlth, Sch Med, Ctr Allergy & Environm ZAUM, Ingolstadter Landstr 1, D-85764 Munich - Germany

^[2] Tech Univ Munich, German Res Ctr Environm Hlth, Helmholtz Ctr Munich, Ingolstadter Landstr 1, D-85764 Munich - Germany

^[3] Tech Univ Munich, German Ctr Lung Res DZL, Ingolstadter Landstr 1, D-85764 Munich - Germany

^[4] Sao Paulo State Univ, Biosci Inst, Dept Gen & Appl Biol, Rio Claro, SP - Brazil

^[5] Polytech Univ Marche, Univ Hosp Ancona, Dept Internal Med, Dept Clin & Mol Sci, Ancona & Allergy Unit, Ancona - Italy

^[6] Justus Liebig Univ Giessen, Dept Dermatol & Allergol, Expt Dermatol & Allergy Res Grp, Giessen - Germany

• Document type: Review article
• Source: CURRENT ALLERGY AND ASTHMA REPORTS; v. 20, n. 10 JUL 9 2020.
• Web of Science Citations: 0

Abstract

Purpose of ReviewStings of Hymenoptera of the superfamily Vespoidea such as yellow jackets, paper wasps or stinging ants are common triggers for severe and even fatal allergic reactions. Antigen 5 allergens are potent allergens in the majority of these venoms with major importance for diagnosis and therapy. Reviewed here are the characteristics of antigen 5 allergens, their role in component-resolved diagnostics as well as current limitations of the available diagnostics for proper therapeutic decisions.Recent FindingsAntigens 5 are proteins of unknown function in Hymenoptera venoms with high allergenic potency. They represent key elements in component-resolved diagnosis to discriminate between honeybee and vespid venom allergy. However, due to their pronounced cross-reactivity, there are remaining diagnostic and therapeutic challenges that have to be addressed.SummaryAntigens 5 are highly relevant venom allergens of the Vespoidea superfamily. Although their use in component-resolved diagnosis facilitates dissection of cross-reactivity and primary allergy in double sensitization to honeybee and vespid venom, new diagnostic concepts are needed to discriminate between allergies to different vespid species. (AU)

• FAPESP's process: 19/02298-3 - Characterization of the immunological potential of the recombinant antigen 5 from Polybia paulista venom
• Grantee: Murilo Luiz Bazon
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 17/07988-2 - Biological and inflammatory evaluation of the antigen 5 from the venom of Polybia paulista (Hymenoptera, Vespidae) in the recombinant form, on cells of macrophagic lineage
• Grantee: Murilo Luiz Bazon
• Support Opportunities: Scholarships in Brazil - Doctorate