Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The regulation of glucose and lipid homeostasis viaPLTPas a mediator ofBAT-liver communication

Full text
Author(s):
Show less -
Sponton, Carlos H. [1, 2, 3, 4] ; Hosono, Takashi [1, 2, 3, 5] ; Taura, Junki [6] ; Jedrychowski, Mark P. [7] ; Yoneshiro, Takeshi [1, 2, 3] ; Wang, Qiang [1, 2, 3] ; Takahashi, Makoto [8] ; Matsui, Yumi [9] ; Ikeda, Kenji [1, 2, 3, 10] ; Oguri, Yasuo [1, 2, 3] ; Tajima, Kazuki [1, 2, 3] ; Shinoda, Kosaku [11, 1, 2, 3] ; Pradhan, Rachana N. [1, 2, 3] ; Chen, Yong [1, 2, 3, 12] ; Brown, Zachary [1, 2, 3] ; Roberts, Lindsay S. [13, 14] ; Ward, Carl C. [13, 14] ; Taoka, Hiroki [15] ; Yokoyama, Yoko [15] ; Watanabe, Mitsuhiro [15] ; Karasawa, Hiroshi [6] ; Nomura, Daniel K. [13, 14] ; Kajimura, Shingo [1, 2, 3, 16]
Total Authors: 23
Affiliation:
Show less -
[1] Univ Calif San Francisco, Diabet Ctr, San Francisco, CA 94143 - USA
[2] Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94131 - USA
[3] Univ Calif San Francisco, Dept Cell & Tissue Biol, San Francisco, CA 94143 - USA
[4] Univ Estadual Campinas, Obes & Comorbid Res Ctr, Biol Inst, Campinas - Brazil
[5] Nihon Univ, Dept Chem & Life Sci, Coll Bioresource Sci, Fujisawa, Kanagawa - Japan
[6] Daiichi Sankyo Co Ltd, End Organ Dis Labs, Tokyo - Japan
[7] Harvard Med Sch, Dept Cell Biol, Boston, MA 02115 - USA
[8] Daiichi Sankyo Co Ltd, Drug Metab & Pharmacokinet Res Labs, Tokyo - Japan
[9] Daiichi Sankyo RD Novare Co Ltd, Prot Prod Res Grp, Biol Res Dept, Tokyo - Japan
[10] Tokyo Med & Dent Univ, Dept Mol Endocrinol & Metab, Tokyo - Japan
[11] Albert Einstein Coll Med, Bronx, NY 10467 - USA
[12] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Endocrinol Internal Med, Wuhan - Peoples R China
[13] Univ Calif Berkeley, Dept Nutr Sci & Toxicol, Berkeley, CA 94720 - USA
[14] Univ Calif Berkeley, Dept Chem Mol & Cell Biol, Berkeley, CA 94720 - USA
[15] Keio Univ, Grad Sch Media & Governance, Yokohama, Kanagawa - Japan
[16] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Div Endocrinol Diabet & Metab, Boston, MA 02115 - USA
Total Affiliations: 16
Document type: Journal article
Source: EMBO REPORTS; JUL 2020.
Web of Science Citations: 0
Abstract

While brown adipose tissue (BAT) is well-recognized for its ability to dissipate energy in the form of heat, recent studies suggest multifaced roles ofBATin the regulation of glucose and lipid homeostasis beyond stimulating thermogenesis. One of the functions involves interorgan communication with metabolic organs, such as the liver, throughBAT-derived secretory factors, a.k.a., batokine. However, the identity and the roles of such mediators remain insufficiently understood. Here, we employed proteomics and transcriptomics in human thermogenic adipocytes and identified previously unappreciated batokines, including phospholipid transfer protein (PLTP). We found that increased circulating levels ofPLTP, via systemic orBAT-specific overexpression, significantly improve glucose tolerance and insulin sensitivity, increased energy expenditure, and decrease the circulating levels of cholesterol, phospholipids, and sphingolipids. Such changes were accompanied by increased bile acids in the circulation, which in turn enhances glucose uptake and thermogenesis inBAT. Our data suggest thatPLTPis a batokine that contributes to the regulation of systemic glucose and lipid homeostasis as a mediator ofBAT-liver interorgan communication. (AU)

FAPESP's process: 16/03682-3 - Inter-organ communication between BAT and muscle: role of batokines in whole body energy homeostasis
Grantee:Carlos Henrique Grossi Sponton
Support type: Scholarships abroad - Research Internship - Post-doctor