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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder

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Gouveia, Flavia Venetucci [1, 2] ; Germann, Juergen [3, 4] ; Devenyi, Gabriel A. [5, 4] ; Morais, Rosa M. C. B. [1, 6] ; Santos, Ana Paula M. [6] ; Fonoff, Erich T. [7] ; Hamani, Clement [2, 8, 9] ; Brentani, Helena [6] ; Chakravarty, M. Mallar [5, 4, 10] ; Martinez, Raquel C. R. [1, 6]
Total Authors: 10
[1] Hosp Sirio Libanes, Sao Paulo - Brazil
[2] Sunnybrook Res Inst, Toronto, ON - Canada
[3] Univ Hlth Network, Montreal, PQ - Canada
[4] McGill Univ, Douglas Mental Hlth Univ Inst, CIC, Montreal, PQ - Canada
[5] McGill Univ, Dept Psychiat, Montreal, PQ - Canada
[6] Univ Sao Paulo, Med Sch, Dept Psychiat, Sao Paulo - Brazil
[7] Univ Sao Paulo, Med Sch, Dept Neurol, Div Funct Neurosurg, Inst Psychiat, Sao Paulo - Brazil
[8] Univ Toronto, Sunnybrook Hlth Sci Ctr, Div Neurosurg, Toronto, ON - Canada
[9] Sunnybrook Hlth Sci Ctr, Harquail Ctr Neuromodulat, Toronto, ON - Canada
[10] McGill Univ, Dept Biol & Biomed Engn, Montreal, PQ - Canada
Total Affiliations: 10
Document type: Journal article
Source: BJPSYCH OPEN; v. 6, n. 5 SEP 2020.
Web of Science Citations: 0

Aggressive behaviour is a highly prevalent and devastating condition in autism spectrum disorder resulting in impoverished quality of life. Gold-standard therapies are ineffective in about 30% of patients leading to greater suffering. We investigated cortical thickness in individuals with autism spectrum disorder with pharmacological-treatment-refractory aggressive behaviour compared with those with non-refractory aggressive behaviour and observed a brain-wide pattern of local increased thickness in key areas related to emotional control and overall decreased cortical thickness in those with refractory aggressive behaviour, suggesting refractoriness could be related to specific morphological patterns. Elucidating the neurobiology of refractory aggressive behaviour is crucial to provide insights and potential avenues for new interventions. (AU)

FAPESP's process: 13/20602-5 - Prospective analyses of the functional results of philanthropist bilateral amygdalectomy in patients with refractory aggression
Grantee:Flavia Venetucci Gouveia
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 11/08575-7 - The role of dopaminergic modulation in the lateral nucleus of amygdala during active avoidance response
Grantee:Raquel Chacon Ruiz Martinez
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 17/10466-8 - Towards revealing aggression: imaging the aggressive brain
Grantee:Flavia Venetucci Gouveia
Support Opportunities: Scholarships abroad - Research Internship - Doctorate