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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Therapeutic applications and delivery systems for triptolide

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Author(s):
Viegas, Juliana Santos Rosa [1] ; Praca, Fabiola Garcia [1] ; Kravicz, Marcelo [1] ; Bentley, Maria Vitoria Lopes Badra [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: DRUG DELIVERY AND TRANSLATIONAL RESEARCH; v. 10, n. 6, SI AUG 2020.
Web of Science Citations: 0
Abstract

Triptolide (TPL) is a natural compound and active component ofTripterygium wilfordiiHook F., an Asian native woody vine widely used for over 200 years in Chinese medicine. Hot water, ethanol-ethyl acetate, and chloroform-methanol extracts are the first reported TPL preparations in the literature, and since then, several studies for application in inflammation processes and cancer are described due to the antitumor, anti-inflammatory, and immunosuppressive characteristics of the molecule. However, physicochemical properties such as poor solubility and bioavailability are the main concerns regarding the TPL safety and efficacy in clinical studies since trials have reported adverse side effects alongside the excellent TPL therapeutic effects. Here, we review the main TPL applications and issues related to the drug usage, and a comprehensive summary of diseases is provided. Special emphasis is given to drug delivery systems designed to overcome the TPL physicochemical characteristics such as poor drug solubility, and how to increase efficacy and obtain a safe drug profile. (AU)

FAPESP's process: 14/50928-2 - INCT 2014: Pharmaceutical Nanotechnology: a transdisciplinary approach
Grantee:Maria Vitória Lopes Badra Bentley
Support type: Research Projects - Thematic Grants
FAPESP's process: 19/04448-2 - Development of a nanostructured lipid carrier containing pool of siRNAs associated with the antitumor agent as a multifunctional therapeutic approach for skin Cancer
Grantee:Juliana dos Santos Rosa
Support type: Scholarships in Brazil - Doctorate