Schmidt, Mariana Costa Braga
Morais, Katia L. P.
[1, 2, 3]
de Almeida, Maira Estanislau Soares
Goldfeder, Mauricio Barbugiani
Chudzinski-Tavassi, Ana Marisa
Total Authors: 6
 Univ Fed Sao Paulo, Dept Biochem, Sao Paulo, SP - Brazil
 Butantan Inst, Lab Mol Biol, Ave Vital Brasil 1500, BR-05503900 Sao Paulo, SP - Brazil
 Butantan Inst, Ctr Excellence New Target Discovery, Sao Paulo, SP - Brazil
Total Affiliations: 3
CELL ADHESION & MIGRATION;
JAN 1 2020.
Web of Science Citations:
In a tumor microenvironment, endothelial cell migration and angiogenesis allow cancer to spread to other organs causing metastasis. Indeed, a number of molecules that are involved in cytoskeleton re-organization and intracellular signaling have been investigated for their effects on tumor cell growth and metastasis. Alongside that, Amblyomin-X, a recombinant Kunitz-type protein, has been shown to reduce metastasis and tumor growth in in vivo experiments. In the present report, we provide a mechanistic insight to these antitumor effects, this is, Amblyomin-X modulates Rho-GTPases and uPAR signaling, and reduces the release of MMPs, leading to disruption of the actin cytoskeleton and decreased cell migration of tumor cell lines. Altogether, our data support a role for Amblyomin-X as a novel potential antitumor drug. (AU)