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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Development of brushite particles synthesized in the presence of acidic monomers for dental applications

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Chiari, Marina D. S. [1] ; Rodrigues, Marcela C. [2] ; Pinto, Mirella F. C. [1] ; Vieira, Douglas N. [1] ; Vichi, Flavio M. [3] ; Vega, Oscar [4] ; Chrzanowski, Wojciech [5] ; Nagaoka, Noriyuki [6] ; Braga, Roberto R. [1]
Total Authors: 9
[1] Univ Sao Paulo, Sch Dent, Dept Biomat & Oral Biol, Av Prof Lineu Prestes 2227, BR-05508000 Sao Paulo, SP - Brazil
[2] Cruzeiro do Sul Univ, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Dept Fundamental Chem, Inst Chem, Sao Paulo - Brazil
[4] Nucl & Energy Res Inst, Ctr Chem & Environm Technol, Sao Paulo - Brazil
[5] Univ Sydney, Sch Pharm, Sydney, NSW - Australia
[6] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Okayama, Okayama - Japan
Total Affiliations: 6
Document type: Journal article
Source: Materials Science & Engineering C-Materials for Biological Applications; v. 116, NOV 2020.
Web of Science Citations: 0

Objectives: To synthesize and characterize brushite particles in the presence of acidic monomers (acrylic acid/AA, citric acid/CA, and methacryloyloxyethyl phosphate/MOEP) and evaluate the effect of these particles on degree of conversion (DC), flexural strength/modulus (FS/FM) and ion release of experimental composites. Methods: Particles were synthesized by co-precipitation with monomers added to the phosphate precursor solution and characterized for monomer content, size and morphology. Composites containing 20 vol% brushite and 40 vol% reinforcing glass were tested for DC, FS and FM (after 24 h and 60 d in water), and 60-day ion release. Data were subjected to ANOVA/Tukey tests (DC) or Kruskal-Wallis/Dunn tests (FS and FM, alpha: 5%). Results: The presence of acidic monomers affected particle morphology. Monomer content on the particles was low (0.1-1.4% by mass). Composites presented similar DC. For FS/24 h, only the composite containing DCPD\_AA was statistically similar to the composite containing 60 vol% of reinforcing glass (without brushite, ``control{''}). After 60 days, all brushite-containing materials showed similar FS, statistically lower than the control composite (p < 0.01). Composites containing DCPD\_AA, DCPD\_MOEP or DCPD\_U ({''}unmodified{''}) showed statistically similar FM/24 h, higher than the control composite. After prolonged immersion, all composites were similar to the control composite, except DCPD\_AA. Cumulative ion release ranged from 21 ppm to 28 ppm (calcium) and 9 ppm to 17 ppm (phosphate). Statistically significant reductions in ion release between 15 and 60 days were detected only for the composite containing DCPD\_MOEP. Significance: Acidic monomers added to the synthesis affected brushite particle morphology. After 60-day storage in water, composite strength was similar among all brushite-containing composites. Ion release was sustained for 60 days and it was not affected by particle morphology. (AU)

FAPESP's process: 17/06446-1 - Effect of calcium orthophosphate composites on microhardness of enamel exposed to cariogenic challenge
Grantee:Mirella Flávia Corrêa Pinto
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 16/50321-6 - Development of calcium phosphate nanoparticles functionalized with acidic monomers for dental remineralization
Grantee:Roberto Ruggiero Braga
Support Opportunities: Regular Research Grants
FAPESP's process: 16/25971-7 - Development and application of calcium phosphate nanoparticles functionalized with acidic monomers for dental remineralization
Grantee:Marina Damasceno e Souza de Carvalho Chiari
Support Opportunities: Scholarships in Brazil - Master