| Author(s): |
Silva, Armenio A. de Carvalho A. da
[1, 2]
;
Sousa, Elcilene A. de
[1]
;
Veras, Marcia D. Alves
[1]
;
Araujo, Bruno Q.
[1]
;
Thevenard, Fernanda
[3]
;
Lago, Joao Henrique G.
[3]
;
Costa-Silva, Thais A.
[3]
;
Tempone, Andre G.
[4]
;
Chaves, Mariana H.
[1]
Total Authors: 9
|
| Affiliation: | [1] Univ Fed Piaui, Dept Quim, BR-64049550 Teresina, PI - Brazil
[2] Inst Fed Educ Ciencia & Tecnol Piaui, BR-64770000 Seo Raimundo Nonato, PI - Brazil
[3] Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210580 Santo Andre, SP - Brazil
[4] Adolfo Lutz Inst, Ctr Parasitol & Micol, BR-01246902 Sao Paulo, SP - Brazil
Total Affiliations: 4
|
In this work, the CH2Cl2 phase from the EtOH extract of Oxandra sessiliflora (Annonaceae) branches was subjected to chromatographic fractionation to afford six sesquiterpenoids: 4 alpha,10 beta-aromadendranediol (1), 4 beta,10 alpha-aromadendranediol (2), 4 alpha,10 alpha-aromadendranediol (3), 1 beta,6 alpha-dihydroxy-4(15)-eudesmene (4), 4 beta,10 alpha-dihydroxy-guai-6-ene (5), and 4 beta,6 beta,7 beta,10 alpha-tetrahydroxy-guaiane (6), the last one identified as a new natural product. The structures of isolated compounds were identified by analysis of NMR and HRESIMS spectral data. Compounds 1-6 exhibited activity against T. cruzi with EC50 values ranging from 16.3-47.5 mu M. Additionally, no cytotoxicity to mammalian cells (NCTC- L929 clone) was observed for tested compounds at the highest concentration (200 mu M). Sesquiterpenes 5 and 6 exhibited higher selectivity index (SI) with values higher than 12.3 and 11.4, respectively. This data suggests that guaiane sesquiterpenes 5 and 6, isolated from O. sessiliflora, may contribute as scaffolds for the design of novel and selective drug candidates for treatment of neglected diseases, mainly for Chagas disease. (AU) |