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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In vitro anti-Trypanosoma cruzi evaluation of sesquiterpenes from the branches of Oxandra sessiliflora

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Silva, Armenio A. de Carvalho A. da [1, 2] ; Sousa, Elcilene A. de [1] ; Veras, Marcia D. Alves [1] ; Araujo, Bruno Q. [1] ; Thevenard, Fernanda [3] ; Lago, Joao Henrique G. [3] ; Costa-Silva, Thais A. [3] ; Tempone, Andre G. [4] ; Chaves, Mariana H. [1]
Total Authors: 9
[1] Univ Fed Piaui, Dept Quim, BR-64049550 Teresina, PI - Brazil
[2] Inst Fed Educ Ciencia & Tecnol Piaui, BR-64770000 Seo Raimundo Nonato, PI - Brazil
[3] Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210580 Santo Andre, SP - Brazil
[4] Adolfo Lutz Inst, Ctr Parasitol & Micol, BR-01246902 Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: PHYTOCHEMISTRY LETTERS; v. 37, p. 59-62, JUN 2020.
Web of Science Citations: 1

In this work, the CH2Cl2 phase from the EtOH extract of Oxandra sessiliflora (Annonaceae) branches was subjected to chromatographic fractionation to afford six sesquiterpenoids: 4 alpha,10 beta-aromadendranediol (1), 4 beta,10 alpha-aromadendranediol (2), 4 alpha,10 alpha-aromadendranediol (3), 1 beta,6 alpha-dihydroxy-4(15)-eudesmene (4), 4 beta,10 alpha-dihydroxy-guai-6-ene (5), and 4 beta,6 beta,7 beta,10 alpha-tetrahydroxy-guaiane (6), the last one identified as a new natural product. The structures of isolated compounds were identified by analysis of NMR and HRESIMS spectral data. Compounds 1-6 exhibited activity against T. cruzi with EC50 values ranging from 16.3-47.5 mu M. Additionally, no cytotoxicity to mammalian cells (NCTC- L929 clone) was observed for tested compounds at the highest concentration (200 mu M). Sesquiterpenes 5 and 6 exhibited higher selectivity index (SI) with values higher than 12.3 and 11.4, respectively. This data suggests that guaiane sesquiterpenes 5 and 6, isolated from O. sessiliflora, may contribute as scaffolds for the design of novel and selective drug candidates for treatment of neglected diseases, mainly for Chagas disease. (AU)

FAPESP's process: 18/10279-6 - Selection and Optimization of New Drug Candidates for Leishmaniasis and Chagas Disease
Grantee:André Gustavo Tempone Cardoso
Support Opportunities: Regular Research Grants
FAPESP's process: 18/07885-1 - Biomolecules from plant species of remnant areas of the Atlantic Forest and Cerrado to treat neglected tropical diseases - chemical and pharmacological aspects
Grantee:João Henrique Ghilardi Lago
Support Opportunities: BIOTA-FAPESP Program - Regular Research Grants