Exercise intensity and physical fitness modulate lipoproteins profile during acute aerobic exercise session

Author(s)

Antunes, B. M. ^[1] ; Rossi, F. E. ^[1] ; Oyama, L. M. ^[2] ; Rosa-Neto, J. C. ^[3] ; Lira, F. S. ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Dept Phys Educ, Exercise & Immunometab Res Grp, Postgrad Program Movement Sci, Presidente Prudente, SP - Brazil

^[2] Univ Fed Sao Paulo, Dept Fisiol, Escola Paulista Med, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Cell Biol & Dev, Immunometab Res Grp, Inst Biome Sci, Sao Paulo - Brazil

• Document type: Journal article
• Source: SCIENTIFIC REPORTS; v. 10, n. 1 MAR 5 2020.
• Web of Science Citations: 1

Abstract

Physical inactivity has emerged as an important cardiometabolic risk factor; however, the beneficial impacts of physical exercise according physical fitness status are still unclear. To analyze the lipoproteins and immune-endocrine response to acute aerobic exercise sessions performed at different intensities according physical fitness status and evaluated the gene expression in monocyte cells. Twelve individuals, divided into Low and High VO2max, performed three randomized acute exercise sessions at low (<60% VO2max), moderate (60-75% VO2max), and high (>90% VO2max) intensities. Blood samples were collected pre, immediately post, and 60 minutes post-exercise to analyze NEFA, triacylglycerol, non-HDL-c, HDL-c, PAI-1, leptin and adiponectin concentrations. Blood samples were collected from another set of twelve individuals for use in monocyte cell cultures to analyze L-CAT, CETP, and AMPK gene expressions. Low VO2max group pre-exercise exhibited higher postprandial leptin and total cholesterol concentrations than High VO2max group (p < 0.05). Exercise performed in highintensity promoted a decreased leptin and NEFA levels (p < 0.05, for both), but for PAI-1 levels was decreased (p < 0.05) only for the Low VO2max group. Triacylglycerol levels decreased after all exercise sessions (p < 0.05) for both groups, and HDL-c exhibited decrease during moderate-intensity (p < 0.05), but this scenario was attenuated in Low VO2max group. Low VO2max individuals exhibit some metabolicendocrine disruption, and acute aerobic exercise sessions performed at low, moderate, and high intensities are capable of modulating metabolic-endocrine parameters, mainly at high-intensity, in a physical fitness-dependent way, given that Low VO2max group was more responsive and seem to be able to appropriate more exercise-related benefits. (AU)

• FAPESP's process: 14/08003-1 - Involvement of the NF-kB and PPAR-gamma in inflammatory and metabolic response in monocytes of sedentary, physically active and trained individuals
• Grantee: Barbara de Moura Mello Antunes
• Support Opportunities: Scholarships in Brazil - Doctorate