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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Enlightening the advancements in electrochemical bioanalysis for the diagnosis of Alzheimer's disease and other neurodegenerative disorders

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Serafin, V [1] ; Gamella, M. [1] ; Pedrero, M. [1] ; Montero-Calle, A. [2] ; Razzino, C. A. [1] ; Yanez-Sedeno, P. [1] ; Barderas, R. [2] ; Campuzano, S. [1] ; Pingarron, J. M. [1]
Total Authors: 9
[1] Univ Complutense Madrid, Fac Chem Sci, Dept Analyt Chem, Madrid 28040 - Spain
[2] Carlos III Hlth Inst, Chron Dis Programme, UFIEC, Madrid 28220 - Spain
Total Affiliations: 2
Document type: Review article
Source: Journal of Pharmaceutical and Biomedical Analysis; v. 189, SEP 10 2020.
Web of Science Citations: 0

Neurodegenerative disorders (NDD), and particularly Alzheimer's disease (AD), are one of the greatest challenges facing our current medicine and society because of its increasing incidence and the high burden imposed both on patients' families and health systems. Despite this, their accurate diagnosis, mostly conducted by cerebrospinal fluid (CSF) analysis or neuroimaging techniques, costly, time-consuming, and unaffordable for most of the population, remains a complex task. In this situation, electrochemical biosensors are flourishing as promising alternative tools for the simple, fast, and low-cost diagnosis of NDD/AD. This review article provides the relevant clinical details of NDD/AD along with the closely related genetic (genetic mutations, polymorphisms of ApoE and specific miRNAs) and proteomic (amyloid-p peptides, total and phosphorylated tau protein) biomarkers circulating mostly in CSF. In addition, the article systematically enlightens a general view of the electrochemical affinity biosensors (mostly aptasensors and immunosensors) reported in the past two years for the determination of such biomark-ers. The different developed strategies, analytical performances and applications are comprehensively discussed. Recent advancements in signal amplification methodologies involving smart designs and the use of nanomaterials and rational surface chemistries, as well as the challenges that must be struggled and the prospects in electrochemical affinity biosensing to bring more accessibility to NDD/AD diagnosis, prognosis, and follow-up, are also pointed out. (C) 2020 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 18/14130-7 - Dendrimer-encapsulated nanoparticles as a sensing platform for Alzheimer´s biomarker detection
Grantee:Claudia Do Amaral Razzino
Support type: Scholarships abroad - Research Internship - Post-doctor